Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Orderly nucleic acid aggregates (ONAAs) self-assembled on mesoporous silica nanoparticles (MSNs) with positively charged aminopropyl groups (PC) were firstly developed. Interestingly, a novel electrostatic DNA self-assembly could realize hybridization chain reaction (HCR) on the surface of PCMSNs in single cells. Significantly, a non-destructive amplification strategy based on ONAAs-PCMSNs was successfully developed for miRNA detection and in situ imaging by the prominent and agminated fluorescence-bright spots in living cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c6an00160b | DOI Listing |
Publication Analysis
Top Keywords
orderly nucleic
8
nucleic acid
8
acid aggregates
8
single cells
8
mirna detection
8
aggregates electrostatic
4
electrostatic self-assembly
4
self-assembly single
4
cells mirna
4
detection visualizing
4