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J Med Chem
September 2025
School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China.
The prevalence of AGA is continuously rising, with an earlier age of onset. Currently, only minoxidil and finasteride have received FDA approval for the treatment of AGA, inadequately addressing the pressing clinical needs. Recently, the involvement of the Wnt/β-catenin signaling pathway in AGA has attracted increased research interest.
View Article and Find Full Text PDFArch Pharm (Weinheim)
September 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Renal ischemia/reoxygenation triggers uremic encephalopathy (UE), culminating in cognitive and neural derangements. Despite its neuroprotective functions, the hippocampal repercussion of the estrogen receptor G protein-coupled estrogen receptor 1 (GPER1) in UE remains uncharted, alongside the prospective involvement of RUNX2. In Silico virtual screening suggested that prunetin (PRU) may activate GPER1 and inhibit RUNX2.
View Article and Find Full Text PDFLife Sci
August 2025
Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China; Enginee
Aims: Sustained oxidative stress (OS) promotes the development of pelvic organ prolapse (POP); however, the pathogenesis of POP under OS conditions remains unclear. This study aimed to investigate the role of serum and glucocorticoid-induced protein kinase 1 (SGK1) in the progression of POP in OS and elucidate its potential molecular mechanisms.
Materials And Methods: The protein levels of SGK1 in fibroblasts and other cells within the uterosacral ligament tissues (ULTs) from patients with POP in OS were measured by immunofluorescence (IF).
Exp Lung Res
September 2025
State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, China.
Recent studies have shown that fine particulate matter (PM2.5) exposure is a key harmful risk factor for chronic obstructive pulmonary disease (COPD) and PM2.5-associated ferroptosis plays an important role during the process of airway oxidative stress.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Department of Medical Biology, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş 46040, Turkey.
This study investigated the regulatory role of the long non-coding RNA maternally expressed gene 3 () in tau hyperphosphorylation and insulin signaling () under high-glucose (HG)-induced neurotoxic conditions mimicking Alzheimer's disease pathology. To explore the function of within a hyperglycemic (Hyp) model, was silenced using small interfering RNA (siRNA) assay, followed by Western blot analysis, qRT-PCR, and network analyses. The si + Hyp group had lower levels of (0.
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