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http://dx.doi.org/10.1053/j.gastro.2015.10.023 | DOI Listing |
Dis Colon Rectum
September 2025
Division of Colon and Rectal Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School.
Background: Individuals born with anorectal and pelvic malformations require lifelong management. Although initially cared for by pediatric providers, these conditions continue to impact patients' health and quality of life into adulthood.
Objective: To assess the prevalence of psychiatric disorders and substance use among adults with congenital colorectal and pelvic malformations, and to explore their distribution across demographic and clinical variables.
J Surg Case Rep
September 2025
Pediatric Surgery Department A, Children Hospital Bechir Hamza, 167, 9th of April Boulevard, Tunis, Tunisia.
We report a case of concurrent congenital diaphragmatic hernia (CDH) and Hirschsprung's disease (HD) in a neonate without syndromic features, representing one of fewer documented cases worldwide. The patient presented with classic CDH symptoms but developed persistent bowel obstruction post-repair, leading to delayed HD diagnosis 4 weeks later. This case highlights the diagnostic challenges in differentiating postoperative ileus from underlying HD in CDH patients.
View Article and Find Full Text PDFUpdates Surg
September 2025
Department of Pediatric Surgery, School of Medicine, Kocaeli University, Izmit, Turkey.
This study aimed to develop an AI-based diagnostic model for Hirschsprung's disease (HD) using deep learning on contrast enema (CE) images, with the goal of improving diagnostic accuracy while reducing invasiveness. The dataset included 725 CE images from histopathologically confirmed HD patients from 2013 to 2022. Employing Python and PyTorch, a deep learning model based on the YOLOv8 algorithm was trained and validated, emphasizing key metrics like mean average precision (mAP), precision, recall, and F1 score.
View Article and Find Full Text PDFFASEB J
September 2025
Department of Biosciences, Rice University, Houston, Texas, USA.
The enteric nervous system (ENS) is the intrinsic nervous system of the gut and controls essential functions, such as gut motility, intestinal barrier function, and water balance. The ENS displays a complex 3D architecture within the context of the gut and specific transcriptional states needed to control gut homeostasis. During development, the ENS develops from enteric neural progenitor cells (ENPs) that migrate into the gut and differentiate into functionally diverse neuron types.
View Article and Find Full Text PDFDown syndrome is a risk factor for Hirschsprung's disease. However, the amniotic band sequence does not directly correlate. We present a patient with Down syndrome and associated Hirschsprung's disease, who exhibited findings consistent with amniotic band sequence.
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