Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Injectable depots that respond to exogenous and endogenous stimuli present an attractive strategy for tunable, patient-specific drug delivery. Here, the design of injectable and multimodal degradable hydrogels that respond to externally applied light and physiological stimuli, specifically aqueous and reducing microenvironments, is reported. Rapid hydrogel formation was achieved using a thiol-maleimide click reaction between multifunctional poly(ethylene glycol) macromers. Hydrogel degradation kinetics in response to externally applied cytocompatible light, reducing conditions, and hydrolysis were characterized, and degradation of the gel was controlled over multiple time scales from seconds to days. Further, tailored release of an encapsulated model cargo, fluorescent nanobeads, was demonstrated.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536978 | PMC |
| http://dx.doi.org/10.1039/C5PY00750J | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Photocrosslinked Mucoadhesive Hyaluronic Acid Hydrogel for Transmucosal Drug Delivery.
J Biomed Mater Res B Appl Biomater
September 2025
Contipro a.s., Czech Republic.
Drug delivery to the central nervous system (CNS) is primarily hindered by the blood-brain barrier (BBB). To address this, mucoadhesive formulations have been designed to prolong residence time at the application site. In this study, we comprehensively characterized the physicochemical and mucoadhesive properties of hyaluronic acid tyramine (HATA) photocrosslinked hydrogels using rheological methods, nanoindentation, contact angle goniometry, and advanced confocal microscopy.
View Article and Find Full Text PDFAn Aggrecanase-Responsive Delivery Hydrogel System of miRNA-17 Facilitates Microfracture-Mediated Articular Cartilage Regeneration by Reprogramming Hostile Inflammatory Niche.
ACS Nano
September 2025
School of Medicine, Nankai University, Tianjin 300071, China.
In situ articular cartilage (AC) regeneration is a meticulously coordinated process. Microfracture has been the most extensive clinical approach in AC repair, but it faces challenges such as matrix degradation, generation, and remodeling within a local inflammatory microenvironment. So far, it remains a challenge to establish a multistage regulatory framework for coordinating these cellular events, particularly the immune response and chondrocyte proliferation in microfracture-mediated AC repair microenvironments, which is crucial for promoting AC regeneration quality.
View Article and Find Full Text PDFLiquid Crystal Sensor Harnessing a Biomimetic Acetylcholinesterase Nanozyme for Detection of Trypsin in Human Serum.
Anal Chem
September 2025
Qilu University of Technology (Shandong Academy of Sciences), Shandong Analysis and Test Center, Jinan 250014, China.
Abnormal levels of trypsin in the human body can lead to various diseases, yet conventional detection methods often lack operational simplicity and real-time readout capabilities. This work presents a state-of-the-art metal organic framework (MOF) nanozyme-integrated liquid crystal (LC) sensor (MHN-LC sensor) and demonstrates the detection of trypsin as a proof of the concept. By rational engineering of the MOF-808 framework with Al and l-histidine coordination, a novel MOF nanozyme (MHis-NE) exhibiting exceptional acetylcholinesterase (AChE)-mimetic activity is successfully prepared.
View Article and Find Full Text PDFMicroenvironment-Programmed siRNA-Based Hydrogel for Spatiotemporal Gene Silencing in Wound Healing.
Adv Mater
September 2025
State Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
Excessive inflammation and overexpressed matrix metalloproteinases (MMPs) are significant factors in the prolonged healing of chronic diabetic wounds. Here, a precise gene therapy strategy is proposed utilizing siRNA and employing intelligent responsive materials for controlled release to mechanistically intervene in the pathological process of chronic non-healing wounds. The system employs a cationic hyperbranched aminoglycoside with disulfide bonds (SS-HPT) as its core delivery mechanism.
View Article and Find Full Text PDFA β-cyclodextrin/AuNPs@MWCNT/chitosan-hydrogel-based 3D stochastic sensor for simultaneous determination of vascular cell adhesion molecule-1, interleukin-6, and natriuretic peptide C-type in whole blood samples.
Mikrochim Acta
September 2025
National Research and Development Institute for Chemistry and Petrochemistry ICECHIM, 202 Splaiul Independentei Street, 060021, Bucharest, Romania.
Molecular recognition and determination of vascular cell adhesion molecule-1 (VCAM-1), interleukin-6 (IL-6), and natriuretic peptide C-type (NPPC) are essential for the early prognosis and diagnosis of cardiovascular diseases, especially in young obese populations. Highly sensitive and selective devices characterized by low Limits of quantification are required for their determination in whole blood. Therefore, a 3D stochastic sensor was developed by immobilizing a chitosan hydrogel onto a carbon paste electrode (used as the support matrix for the hydrogel), which was subsequently modified with gold nanoparticles, multi-walled carbon nanotubes, and β-cyclodextrin (β-CD/AuNPs@MWCNT/CS/CPE).
View Article and Find Full Text PDF