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Objective: Delayed enteral nutrition, defined as enteral nutrition started 48 hours or more after admission to the PICU, is associated with an inability to achieve full enteral nutrition and worse outcomes in critically ill children. We reviewed nutritional practices in six medical-surgical PICUs and determined risk factors associated with delayed enteral nutrition in critically ill children.
Design: Retrospective cross-sectional study using medical records as source of data.
Setting: Six medical-surgical PICUs in northeastern United States.
Patients: Children less than 21 years old admitted to the PICU for 72 hours or more excluding those awaiting or recovering from abdominal surgery.
Measurements And Main Results: A total of 444 children with a median age of 4.0 years were included in the study. Enteral nutrition was started at a median time of 20 hours after admission to the PICU. There was no significant difference in time to start enteral nutrition among the PICUs. Of those included, 88 children (19.8%) had delayed enteral nutrition. Risk factors associated with delayed enteral nutrition were noninvasive (odds ratio, 3.37; 95% CI, 1.69-6.72) and invasive positive-pressure ventilation (odds ratio, 2.06; 95% CI, 1.15-3.69), severity of illness (odds ratio for every 0.1 increase in pediatric index of mortality 2 score, 1.39; 95% CI, 1.14-1.71), procedures (odds ratio, 3.33; 95% CI, 1.67-6.64), and gastrointestinal disturbances (odds ratio, 2.05; 95% CI, 1.14-3.68) within 48 hours after admission to the PICU. Delayed enteral nutrition was associated with failure to reach full enteral nutrition while in the PICU (odds ratio, 4.09; 95% CI, 1.97-8.53). Nutrition consults were obtained in less than half of the cases, and none of the PICUs used tools to assure the adequacy of energy and protein nutrition.
Conclusions: Institutions in this study initiated enteral nutrition for a high percentage of patients by 48 hours of admission. Noninvasive positive-pressure ventilation was most strongly associated with delay enteral nutrition. A better understanding of these risk factors and assessments of nutritional requirements should be explored in future prospective studies.
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http://dx.doi.org/10.1097/PCC.0000000000000527 | DOI Listing |
Croat Med J
August 2025
Sara Sila, Department of Pediatrics, Referral Center for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Klaićeva 16, 10000 Zagreb, Croatia,
Aim: To assess the efficacy of a multidisciplinary tube-weaning program.
Methods: This retrospective cohort study enrolled children with feeding tube dependency who had not responded to standard tube-weaning interventions. All participants underwent a structured two-week multidisciplinary tube weaning delivered in a day-hospital setting at the Children's Hospital Zagreb in the period from August 2016 to February 2023.
Nutr Clin Pract
September 2025
Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USA.
Home parenteral nutrition (HPN) is a life-sustaining therapy traditionally used as a bridge to enteral autonomy or intestinal transplantation. Increasingly, it is used for intractable feeding intolerance (IFI), which can occur near the end of life (EOL) in children with severe neurological impairment (SNI). In these cases, HPN use differs from its historical role and requires tailored outpatient planning.
View Article and Find Full Text PDFNutr Clin Pract
September 2025
Department of Pediatrics, Mercer University School of Medicine, Macon, Georgia, USA.
Background: The purpose of our study was to describe the time to full oral enteral feeding for extremely low birth weight (ELBW) infants in the neonatal intensive care unit (NICU).
Methods: We conducted a retrospective chart review of ELBW infants born at a regional medical center between July 1, 2021, and December 31, 2022. Infants who died or were transferred before discharge from the NICU were excluded from the study.
JPEN J Parenter Enteral Nutr
September 2025
Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada.
Background: Intravenous lipid emulsions are a key component of parenteral nutrition, and their fatty acid compositions may influence immune responses and clinical outcomes.
Methods: This retrospective cohort study conducted from January 2020 to December 2022 compared clinical outcomes of hospitalized non-critical care patients receiving parenteral nutrition with either mixed oil or soybean oil lipid emulsions for at least 48 h. The primary outcome was a composite of the presence of pneumonia, urinary tract infection, or an intra-abdominal collection diagnosed within 14 days of initiating parenteral nutrition.
Cerebellum
September 2025
Department of Neurology, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Multiple system atrophy (MSA) is a progressive, adult-onset neurodegenerative disorder involving autonomic failure, cerebellar ataxia, and parkinsonism. Patients often require invasive interventions, such as gastrostomy or tracheostomy, and sudden death is common. This study aimed to elucidate patterns of invasive treatment and identify risk factors for tracheostomy or sudden death within 5 years of onset.
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