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PLoS One
September 2025
Department of Cardiology Ullevaal, Oslo University Hospital, Oslo, Norway.
Background: The gut microbiota produces numerous metabolites that can enter the circulation and exert effects outside the gut. Several studies have reported altered gut microbiota composition and circulating metabolites in patients with chronic heart failure (HF) compared to healthy controls. Limited data is available on the interplay between dysbiotic features of the gut microbiota and altered circulating metabolites in HF patients.
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September 2025
Faculty of Environmental, Climate Change and Urban Studies, National Economics University (NEU), Hanoi, Vietnam.
This study aims to assess the livelihood vulnerability to climate change of ethnic minority communities in Yen Bai province, a typical mountainous region in northern Vietnam. Utilizing the Livelihood Vulnerability Index (LVI) framework developed by Hahn et al. (2009), in combination with the IPCC vulnerability structure, the research analyzes eight components related to household characteristics, health, food, water, housing and productive land, social and financial networks, livelihood strategies, and exposure to climate shocks.
View Article and Find Full Text PDFHepatitis C (HCV) infection is a major global health challenge, with particularly high prevalence among people who inject drugs (PWID) in the Eastern European and Central Asian region (EECA). While the country of Georgia has made major progress in reducing overall HCV prevalence, less is known about HCV reinfection rates and risk factors for reinfection among PWID. In this study, we aimed to: (1) estimate HCV reinfection rates and (2) identify risk factors associated with HCV reinfection among PWID.
View Article and Find Full Text PDFLangmuir
September 2025
School of Material Science and Chemical Engineering, Harbin University of Science and Technology, Harbin 150040, China.
Electrochemical sensors capable of detecting different types of biomolecules using a single electrode are highly desirable for simplifying analytical platforms and expanding their practical applicability. Herein, we develop a multifunctional electrochemical sensor based on a 3D honeycomb-like porous rGO/PPy-POM composite film for the independent detection of dopamine (DA) and folic acid (FA), two chemically distinct and clinically relevant biomolecules. The electrode is fabricated through a facile, low-cost, and environmentally friendly breath figure method to create a 3D porous reduced graphene oxide (rGO) framework, followed by codeposition of polypyrrole (PPy) and polyoxometalates (POMs).
View Article and Find Full Text PDFEnviron Sci Technol
September 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
While the cancer genome is well-studied, the nongenetic exposome of cancer remains elusive, particularly for regionally prevalent cancers with poor prognosis. Here, by employing a combined knowledge- and data-driven strategy, we profile the chemical exposome of plasma from 53 healthy controls, 14 esophagitis and 101 esophageal squamous cell carcinoma (ESCC) patients, and 46 esophageal tissues across 12 Chinese provinces, integrating inorganic, endogenous, and exogenous chemicals. We first show that components of the ESCC chemical exposome mediate the relationship between ESCC-related dietary/lifestyle factors and clinic health status indicators.
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