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http://dx.doi.org/10.1371/journal.pgen.1005266 | DOI Listing |
Clin Neurophysiol
August 2025
Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Objective: This study presents a comprehensive analysis of electrochemical skin conductance (ESC) values collected from over 1.9 million measurements using Withings Body Scan and Body Comp scales. It aimed at establishing descriptive values for ESC while correcting for the influence of age, sex, and circadian and seasonal variations on sudomotor function.
View Article and Find Full Text PDFImmun Inflamm Dis
September 2025
School of Clinical Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Aim: Autoimmune diseases, characterized by the immune system mistakenly attacking the body's own tissues, are a growing global concern, with increasing prevalence. The circadian clock is a fundamental regulator of physiological processes, critically modulating immune functions. This review explores the intricate connections between circadian rhythms and immune responses in autoimmune pathogenesis and how disruptions exacerbate disease.
View Article and Find Full Text PDFChronobiol Int
September 2025
Faculty of Medicine & Health, School of Health Sciences, The University of Sydney, Sydney, Australia.
This study examines how dietary nutrient patterns vary among individuals with different chronotypes. In other words, this research explores the potential connections between nutrient intake and circadian rhythm. In this secondary data analysis, we used data from 3,072 adult participants (mean age: 30.
View Article and Find Full Text PDFSci Adv
September 2025
Department of Biology, Indiana University Bloomington, Bloomington, 47401 IN, USA.
Neuronal connectivity in the circadian clock network is essential for robust endogenous timekeeping. In the circadian clock network, the small ventral lateral neurons (sLNs) serve as critical pacemakers. Peptidergic communication mediated by the neuropeptide (PDF), released by sLNs, has been well characterized.
View Article and Find Full Text PDFJ Glob Health
August 2025
Background: Recent studies have established a connection between circadian rhythm disruption and the development of type 2 diabetes mellitus (T2DM), yet the underlying genetic mechanisms remain inadequately understood. This research aims to elucidate the causal relationships between circadian rhythm-related genes and T2DM by utilising a multi-omics approach.
Methods: The study employed the GeneCards database to identify genes associated with circadian rhythms.