Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The effect of dysprosium(III) triflate on macrolactonization reactions to form depsipeptides using MNBA (Shiina's reagent) is reported. Improved yields were obtained for the formation of 16-membered depsipeptides using lanthanide triflate additives. The use of a macrocyclization strategy permits the use of a semiautomated solid-phase synthesis approach for the rapid synthesis of analogues of the antibacterial A54556 acyldepsipeptides in only two physical operations, requiring only final product purification after cyclization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.5b00781 | DOI Listing |
Publication Analysis
Top Keywords
synthesis approach
8
lanthanideiii triflate
4
triflate mediated
4
mediated macrolactonization/solid-phase
4
synthesis
4
macrolactonization/solid-phase synthesis
4
approach depsipeptide
4
depsipeptide synthesis
4
synthesis dysprosiumiii
4
dysprosiumiii triflate
4