Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We propose a novel concept and tool kit for predictive phenotyping. The proposed technology measures respiration properties as functions of growth conditions to identify genotypes with higher plasticity via homeostasis and adaptive morphophysiology. Combining calorespirometry, oxygen isotope analysis and functional-marker-assisted selection ('CalOxy-FMAS') for genotype screening will enable predicting the genetic potential for stable plant growth performance. Application of this novel tool kit can help identify genotypes with controlled homeostasis in changing environments and optimized growth performance. Simultaneously, it will allow a better balance in breeding for high yields and quality characteristics. Applying 'CalOxy-FMAS' can efficiently narrow the pool of genotypes to be screened for final phenotyping in the field.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/bfgp/elv008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Raman-based PAT for multi-attribute monitoring during VLP recovery by dual-stage CFF: attribute-specific spectral preprocessing for model transfer.
Front Bioeng Biotechnol
August 2025
Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Spectroscopic soft sensors are developed by combining spectral data with chemometric modeling, and offer as Process Analytical Technology (PAT) tools powerful insights into biopharmaceutical processing. In this study, soft sensors based on Raman spectroscopy and linear or partial least squares (PLS) regression were developed and successfully transferred to a filtration-based recovery step of precipitated virus-like particles (VLPs). For near real-time monitoring of product accumulation and precipitant depletion, the dual-stage cross-flow filtration (CFF) set-up was equipped with an on-line loop in the second membrane stage.
View Article and Find Full Text PDFA systematic analysis of contemporary whole exome sequencing capture kits to optimise high-coverage capture of CCDS regions.
NAR Genom Bioinform
September 2025
Department of Human Genetics and Genomic Medicine, University of Southampton, Southampton, SO16 6YD, UK.
Whole exome sequencing (WES) is a well-established tool for clinical diagnostics, is more cost-effective and faster to analyse than whole genome sequencing and has been implemented to uplift diagnostic rates in human disease. However, challenges remain to achieve comprehensive and uniform coverage of targets, and high sensitivity and specificity. Differences in genomic target regions and exome capture mechanism between kits may lead to differences in overall coverage uniformity and capture efficiency.
View Article and Find Full Text PDFAutomatic trending and analysis of SPECT quality assurance with artificial intelligence optical character recognition.
Med Phys
August 2025
The University of Texas MD Anderson Cancer Houston, Houston, Texas, USA.
Background: To guarantee high-quality patient scans, thorough quality assurance (QA) of SPECT or gamma cameras, including performance, review, and documentation, is essential.
Purpose: We developed a novel Nuclear Medicine Quality Assurance server (NMQA) with an AI deep learning (AIDL) optical character recognition (OCR) system to automate QA data retrieval and review from SPECT and gamma cameras. The system extracts and compares daily and weekly QA data against specifications.
High-efficiency chemiluminescent POCT assay for anti-Müllerian hormone: innovative development and application in polycystic ovary syndrome diagnosis.
Anal Methods
September 2025
School of Biotechnology, Jiangnan University, Wuxi 214122, China.
In recent years, the decline in ovarian reserve function has become a major cause of reduced female fertility. Early identification, evaluation, and management of ovarian reserve dysfunction are essential for improving female fertility and reproductive health. Currently, the main diagnostic method is assessing ovarian function through measuring AMH serum concentration and follicle count.
View Article and Find Full Text PDFCombining Correlative Cryogenic Fluorescence and Electron Microscopy and Correlative Cryogenic Super-Resolution Fluorescence and X-Ray Tomography-Novel Complementary 3D Cryo-Microscopy Across Scales to Reveal Nanoparticle Internalization Into Cancer Cells.
Microsc Res Tech
September 2025
Center for Optical Technologies, Aalen University, Aalen, Germany.
Understanding the intracellular fate of nanoparticles (NPs) is essential for advancing nanomedicine, particularly in targeted drug delivery for cancer therapy. Here, we present a complementary cryogenic microscopy workflow across scales to investigate the uptake and subcellular localization of zirconyl-containing inorganic-organic hybrid nanoparticles (IOH-NPs) in murine breast cancer cells. Our approach integrates cryogenic fluorescence microscopy (cryo-FM), cryo-focused ion beam scanning electron microscopy (cryo-FIBSEM), and cryo-soft X-ray tomography (cryo-SXT), enabling molecular specificity, high-resolution imaging, and volumetric ultrastructural analysis in near-native cellular states.
View Article and Find Full Text PDF