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Purpose: The purpose of this article is to review the mechanical requirements of the tissue-implant interface and analyze related theories.
Study Selection: The osseointegration capacity of titanium implants has been investigated over the past 50 years. We considered the ultimate goal of osseointegration to which form a desirable interfacial layer and a bone matrix with adequate biomechanical properties.
Results: Occasionally, the interface comprises porous titanium and bone ingrowth that enables a functionally graded Young's modulus, thereby allowing reduction of stress shielding. However, the optimal biomechanical connection at the interface has not yet been fully clarified. There have been publications supporting several universal mechanical testing technologies in terms of bone-titanium bonding ability, although the separation of newly formed bone quality is unlikely.
Conclusions: The understanding of complex mechanical bone behavior and size-dependent properties ranging from a nano- to a macroscopic level are essential in the biomechanical optimization of implants. The requirements of regenerated tissue at the interface include high strength, fracture toughness related to ductility, and time-dependent energy dissipation and/or elastic-plastic stress distribution. Moreover, a strong relationship between strain signals and peri-implant tissue turnover could be expected, so that ideal implant biomechanics may enable longevity via adaptive bone remodeling.
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http://dx.doi.org/10.1016/j.jpor.2015.01.003 | DOI Listing |
Nanoscale
September 2025
School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 611731, China.
Although improving the charging cutoff voltage is an effective strategy to increase its capacity, LiCoO ("LCO") undergoes rapid capacity decay due to severe structural and interface degradations at high voltages. Herein, we proposed a multifunctional surface modification by coating nano-sized entropy materials (Li-La-Ti-Zr-Co-O, Nano-MEO). Nano-MEO rivets were constructed on the surface of LCO, which stabilized the fragile surface.
View Article and Find Full Text PDFMater Today Bio
October 2025
Leibniz Institute of Polymer Research Dresden, Division Polymer Biomaterials Science, Max Bergmann Center of Biomaterials Dresden, 01069, Dresden, Germany.
Glycosaminoglycan-based biohybrid hydrogels represent a powerful class of cell-instructive materials with proven potential in tissue engineering and regenerative medicine. Their biomedical functionality relies on a nanoscale polymer network that standard microscopy techniques cannot resolve. Here, we introduce an advanced analytical approach that integrates transmission electron microscopy, X-ray scattering, and computer simulations to directly and quantitatively characterize the nanoscale molecular network structure of these hydrogels.
View Article and Find Full Text PDFACS Electrochem
September 2025
Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemigården 4, Gothenburg 412 96, Sweden.
Carbon fiber nanotip electrodes (CFNEs) are crucial for electrochemical recordings of neurotransmission release in confined spaces, such as synapses and intracellular measurements. However, fabricating CFNEs with small surface area to minimize noise remains challenging due to inconsistent tip size control, low reproducibility, and low fabrication success rate. Here, we present a reliable, user-friendly method with high reproducibility and success rate for precise CFNE fabrication using microscopy-guided electrochemical etching of cylindrical carbon fiber microelectrodes in a potassium hydroxide droplet.
View Article and Find Full Text PDFACS Electrochem
September 2025
Liquid Sunlight Alliance, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Reaction rate coefficients for electron-transfer processes at the electrode-electrolyte interface are commonly estimated by using the Butler-Volmer equation, but their values are inaccurate beyond a few tenths of volts of overpotential. The Marcus-Hush-Chidsey (MHC) formalism yields correct asymptotic behavior of the rate coefficients vs applied overpotential but has complex dependencies on the redox system's intrinsic parameters, which can be difficult to model or measure. In this work, we bridge the two kinetics formalisms to estimate the reorganization energy, one of the important parameters for the MHC formalism, and investigate its dependence on other intrinsic parameters such as activation barriers, electronic coupling strength, and the density of states of the electrode surface.
View Article and Find Full Text PDFACS Electrochem
September 2025
Department of Material Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Bipolar membranes (BPMs) are increasingly recognized as a promising electrolyte option for water electrolysis, attributable to their distinctive properties derived from the membrane's layered structure, which consists of an anion exchange (AEL) and a cation exchange layer (CEL). This study investigates four different BPMs and the influence they have on the performance of a water electrolysis cell under two different feed configurations: (1) a symmetric deionized water feed to both anode and cathode compartments and (2) an asymmetric feed with a 0.5 mol/L NaCl catholyte feed and a deionized water anolyte feed.
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