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By using catalytic amount of CoCl2 with dmgH (dimethylglyoxime) as ligand to form a photosensitizer in situ, a highly selective, efficient, and environmentally benign visible light mediated cross-dehydrogenative coupling (CDC) reaction has been developed in aqueous medium. The desired cross-coupling C-C bonds that involve Csp3 with Csp, Csp2, and Csp3, respectively, were achieved exclusively in high yields without formation of any other byproduct.
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http://dx.doi.org/10.1021/ol503744a | DOI Listing |
J Am Chem Soc
September 2025
Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, Texas 75080-3021, United States.
The direct transformation of C-H bonds into C-C bonds via cross-dehydrogenative coupling (CDC) represents a powerful strategy in synthetic chemistry, enabling streamlined bond construction without the need for prefunctionalized substrates. While traditional CDC approaches rely on polar mechanisms and preactivation of one of the C-H partners, recent advances have introduced radical-based strategies that employ a hydrogen atom transfer (HAT) approach to access carbon-centered radicals from unactivated substrates. Herein, we report a nickel-catalyzed CDC reaction between aldehydes and alkenes for the synthesis of skipped enones, leveraging aryl radicals as intermolecular HAT agents.
View Article and Find Full Text PDFJ Colloid Interface Sci
August 2025
School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China. Electronic address:
An efficient two-step sequential supramolecular artificial light-harvesting system has been successfully constructed using self-assembled nanoparticles of cyanostilbene-cored dendrimers (CS-1 and CS-2) as donors, along with the fluorescent dye Nile red (NiR) and near-infrared (NIR) emitter MTSIC as acceptors in aqueous media. Through supramolecular interactions, the dendritic assemblies efficiently transfer energy in a sequential manner, first to NiR and then to MTSIC, resulting in an exceptionally high antenna effect (up to 97.7) and near-quantitative energy transfer efficiencies (reaching 99.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
August 2025
Guangdong Provincial Key Laboratory of Carbon Dioxide Resource Utilization, School of Chemistry, South China Normal University, Guangzhou, 510006, P.R. China.
The cross-dehydrogenative coupling (CDC) of tertiary amines and terminal alkynes is a vital catalysis step in the manufacture of C─C bonds. The traditional thermal catalysis, utilizing noble metal salts or toxic solvents, generally results in relatively low atom economy or unmet sustainable development prospect. The challenge of the CDC reactions lies in the simultaneous activation of C─H bonds in terminal alkynes and formation of free radical activation of tertiary amines to achieve the C─C coupling, which calls for novel catalytic techniques and powerful catalysts.
View Article and Find Full Text PDFDalton Trans
August 2025
Department of Organic and Polymer Chemistry; Hunan Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering; Central South University, Changsha, Hunan-410083, China.
Porous organic polymers (POPs) serve a key function as transition metal carriers and have attracted widespread attention in the catalysis field. However, a preferred and universal transition metal carrier remains elusive. In this study, we designed and synthesized a preferred 2,2':6',2''-terpyridine-containing building motif and prepared a POP (POP-Tpy-1) the Buchwald-Hartwig coupling reaction of a diamino-linker and trisbromo-node.
View Article and Find Full Text PDFOrg Biomol Chem
August 2025
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu-632014, India.
The cross-dehydrogenative coupling reactions have gained supreme importance owing to their synthetic efficiency in accessing simple to complex organic molecules. Herein, we report a Ru(II)-catalyzed directing group-assisted CDC reaction between 2-arylphthalazin-1(2)-one and heteroarenes. This methodology offers advantages such as excellent regio-selectivity with good functional group compatibility, resulting in a broad substrate scope.
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