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Given a collection of images, where each image contains several faces and is associated with a few names in the corresponding caption, the goal of face naming is to infer the correct name for each face. In this paper, we propose two new methods to effectively solve this problem by learning two discriminative affinity matrices from these weakly labeled images. We first propose a new method called regularized low-rank representation by effectively utilizing weakly supervised information to learn a low-rank reconstruction coefficient matrix while exploring multiple subspace structures of the data. Specifically, by introducing a specially designed regularizer to the low-rank representation method, we penalize the corresponding reconstruction coefficients related to the situations where a face is reconstructed by using face images from other subjects or by using itself. With the inferred reconstruction coefficient matrix, a discriminative affinity matrix can be obtained. Moreover, we also develop a new distance metric learning method called ambiguously supervised structural metric learning by using weakly supervised information to seek a discriminative distance metric. Hence, another discriminative affinity matrix can be obtained using the similarity matrix (i.e., the kernel matrix) based on the Mahalanobis distances of the data. Observing that these two affinity matrices contain complementary information, we further combine them to obtain a fused affinity matrix, based on which we develop a new iterative scheme to infer the name of each face. Comprehensive experiments demonstrate the effectiveness of our approach.
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http://dx.doi.org/10.1109/TNNLS.2014.2386307 | DOI Listing |
RSC Chem Biol
August 2025
Department of Chemistry - BMC, Uppsala University Sweden
Analysis of ligand-induced structural changes in proteins is challenging due to the lack of experimental methods suited for detection and characterisation of both ligand binding and induced structural changes. We have explored biosensors with different detection principles to study interactions between ligands and acetylcholine binding proteins (AChBPs), soluble homologues of Cys-loop ligand gated ion channels (LGICs) that undergo similar structural changes as LGICs upon ligand binding. X-ray crystallography was used to identify binding sites and establish if the detected conformational changes involved small changes in loop C or major structural changes in the pentamer associated with ion channel opening.
View Article and Find Full Text PDFMolecules
August 2025
Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK.
The development of molecules that interact with G-quadruplex (G4) sequences requires effective evaluation methods. Several techniques are currently available, including nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, surface plasmon resonance (SPR), isothermal titration calorimetry (ITC) and mass spectrometry (MS), fluorescence using FRET-melting, G4-fluorescent intercalator displacement assay (G4-FID) and affinity chromatography. Among these, CD spectroscopy is gaining prominence due to its lower material requirements, faster experimentation and quicker data processing.
View Article and Find Full Text PDFAnal Methods
August 2025
Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation & Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Pharmaceutical Engineering, Changsha University of Science and Technology, Changsha 410114, China.
Enantioselective discrimination of chiral amino acids is critically important across biomedicine, pharmacology, and food science, given the distinct biological roles of D- and L-enantiomers. In this study, a novel chiral sensor based on walnut-shaped molecularly imprinted polymers (w-MIPs) was developed for the highly sensitive and selective recognition of D- and L-arginine (Arg). The unique core-shell w-MIPs architecture, containing targeted binding sites, was synthesized tailored precipitation polymerization and characterized using transmission electron microscopy (TEM), atomic force microscopy (AFM), and Fourier transform infrared spectroscopy (FT-IR).
View Article and Find Full Text PDFPlant Cell Physiol
August 2025
Institute of Plant Science and Resources, Okayama University, Kurashiki, Okayama, 710-0046, Japan.
Abscisic acid (ABA) signaling in stomatal guard cells is crucial for plants to cope with abiotic stress condition. Pyrabactin is a synthetic agonist of ABA that has a selective affinity to limited isoforms of ABA receptors. Here we investigated the differential utilization of downstream signaling events in guard cell ABA signaling under specific receptor isoforms taking advantage of pyrabactin affinity.
View Article and Find Full Text PDFIn Silico Pharmacol
August 2025
Department of Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Pondicherry 605014 India.
Unlabelled: Rho-associated coiled-coil kinase 1 (ROCK1) and transforming growth factor-beta receptor 1 (TGFBR1) plays crucial roles in epithelial-mesenchymal transition (EMT), cytoskeleton remodeling, cell adhesion, and tumor metastasis. Targeting both ROCK1 and TGFBR1 simultaneously offers a strategic approach to disrupt these pathways, potentially leading to more effective treatments for cancer metastasis. To identify dual inhibitors, a multifaceted computational approach integrating pharmacophore modeling, molecular docking, and molecular dynamics (MD) simulations was employed.
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