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Neurology
October 2025
Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network on Rare and Complex Epilepsies - EpiCARE, Rome, Italy.
Objectives: Neuronal ceroid lipofuscinosis type 3 (CLN3) is a rare lysosomal storage disorder characterized by progressive neurodegeneration. No disease-modifying treatments are currently available. Miglustat, a substrate reduction therapy, has shown preclinical efficacy in CLN3 models (conference abstract).
View Article and Find Full Text PDFPLoS One
September 2025
Internal Medicine Department, Tlemcen University Hospital, Tlemcen, Algeria.
Background: Visceral adipose tissue (VAT) is associated with several cardiometabolic risk factors, particularly metabolic syndrome and insulin resistance. Reference values for VAT vary across populations, genders, and ages. Data on visceral fat in the Algerian population are lacking.
View Article and Find Full Text PDFAnn Afr Med
September 2025
Department of Preventive and Social Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Aims: The aim of the study was to evaluate the accuracy of two devices that measure hemoglobin (Hb) from blood samples taken from small capillary tubes (HemoCue® Hb 301 System) and another from whole blood taken from veins or arteries (Horiba H550) with a laboratory reference analyzer (Beckman Coulter DxH 520).
Subjects And Methods: A cross-sectional study was conducted, in which capillary and venous blood samples were taken from 529 individuals across outpatient and inpatient wards of both genders, with an age range from 7 to 83 years. The accuracy and agreement were statistically evaluated using Lin's concordance correlation coefficient.
JMIR Med Inform
September 2025
Department of Radiology, Air Force Medical Center, Air Force Medical University, Fucheng Road 30, Haidian District, Beijing, CN.
Background: Lateral malleolar avulsion fracture (LMAF) and subfibular ossicle (SFO) are distinct entities that both present as small bone fragments near the lateral malleolus on imaging, yet require different treatment strategies. Clinical and radiological differentiation is challenging, which can impede timely and precise management. On imaging, magnetic resonance imaging (MRI) is the diagnostic gold standard for differentiating LMAF from SFO, whereas radiological differentiation on computed tomography (CT) alone is challenging in routine practice.
View Article and Find Full Text PDFJ Neurooncol
September 2025
Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Rationale And Objectives: Double expression lymphoma (DEL) is an independent high-risk prognostic factor for primary CNS lymphoma (PCNSL), and its diagnosis currently relies on invasive methods. This study first integrates radiomics and habitat radiomics features to enhance preoperative DEL status prediction models via intratumoral heterogeneity analysis.
Materials And Methods: Clinical, pathological, and MRI imaging data of 139 PCNSL patients from two independent centers were collected.