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Different aspects of recognition memory in rodents are commonly assessed using variants of the spontaneous object recognition procedure in which animals explore objects that differ in terms of their novelty, recency, or where they have previously been presented. The present article describes three standard variants of this procedure, and outlines a theory of associative learning, SOP which can offer an explanation of performance on all three types of task. The implications of this for theoretical interpretations of recognition memory and the procedures used to explore it are discussed.
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http://dx.doi.org/10.1016/j.bbr.2014.10.046 | DOI Listing |
J Mol Neurosci
September 2025
Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
The ketogenic diet (KD), a high-fat, low-carbohydrate regimen, has been shown to exert neuroprotective effects in various neurological models. This study explored how KD-alone or combined with antibiotic-induced gut microbiota depletion-affects cognition and neuroinflammation in aging. Thirty-two male rats (22 months old) were assigned to four groups (n = 8): control diet (CD), ketogenic diet (KD), antibiotics with control diet (AB), and antibiotics with KD (KDAB).
View Article and Find Full Text PDFExp Neurobiol
August 2025
Department of Biological Sciences, Konkuk University, Seoul 05029, Korea.
This study investigated the learning strategy preferences of 11-month-old APP/PS1 double transgenic (Tg) mice, a well-established murine model of Alzheimer's disease (AD). APP/PS1 Tg and non-Tg control mice were serially trained in visual and hidden platform tasks in the Morris water maze. APP/PS1 Tg mice performed poorly in visual platform training compared with non-Tg mice but performed as well as non-Tg mice in hidden platform training.
View Article and Find Full Text PDFPharmacol Biochem Behav
September 2025
Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Universidad de Málaga (UMA), Málaga, 29010, Spain; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Málaga, Spain. Electronic address:
Adolescence is a period of heightened neuroplasticity and vulnerability to environmental insults, including drug exposure. In this study, we investigated the short- and long-term behavioral effects, as well as the long-term hippocampal effects, of chronic cocaine administration during adolescence, along with the potential neuroprotective role of insulin-like growth factor 2 (IGF2) in male C57BL/6J mice. Over 21 days, mice received daily intraperitoneal injections of saline, cocaine, IGF2, or a combination of cocaine and IGF2.
View Article and Find Full Text PDFCogn Psychol
September 2025
Graduate School of Engineering, Kochi University of Technology, Kami, Kochi, Japan. Electronic address:
Prior researches on global-local processing have focused on hierarchical objects in the visual modality, while the real-world involves multisensory interactions. The present study investigated whether the simultaneous presentation of auditory stimuli influences the recognition of visually hierarchical objects. We added four types of auditory stimuli to the traditional visual hierarchical letters paradigm:no sound (visual-only), a pure tone, a spoken letter that was congruent with the required response (response-congruent), or a spoken letter that was incongruent with it (response-incongruent).
View Article and Find Full Text PDFTurk J Pediatr
September 2025
Division of Developmental Pediatrics, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Background: Autism spectrum disorder (ASD) is more frequently diagnosed in boys than in girls, possibly due to gender-based differences in symptom presentation or referral patterns. This study investigates gender-related variations in symptom severity and clinical presentation among preschool children referred for suspected ASD.
Methods: This study included 125 children (boys: n=103; girls: n=22) aged 2-5 years suspected of having ASD.