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A promising technique for oil encapsulation in Ca-alginate capsules by inverse gelation was proposed by Abang et al. This method consists of emulsifying calcium chloride solution in oil and then adding it dropwise in an alginate solution to produce Ca-alginate capsules. Spherical capsules with diameters around 3 mm were produced by this technique, however the production of smaller capsules was not demonstrated. The objective of this study is to propose a new method of oil encapsulation in a Ca-alginate membrane by inverse gelation. The optimisation of the method leads to microcapsules with diameters around 500 μm. In a search of microcapsules with improved diffusion characteristics, the size reduction is an essential factor to broaden the applications in food, cosmetics and pharmaceuticals areas. This work contributes to a better understanding of the inverse gelation technique and allows the production of microcapsules with a well-defined shell-core structure.
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http://dx.doi.org/10.3109/02652048.2014.985342 | DOI Listing |
Lab Chip
September 2025
Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.
Block copolymer fluorosurfactants are frequently utilized to stabilize water-oil interfaces in droplet microfluidics, enabling parallel and compartmentalized biochemical reactions within individual droplets. Surfactants are able to self-assemble into inverse micelles with the concentration exceeding the critical micelle concentration (CMC), which has been identified as the main reason causing cross-contamination among droplets. This study explored the possibility to utilize the inverse micelles for passive cargo delivery from the fluorocarbon oil phase into the aqueous droplet interior, which has rarely been studied previously.
View Article and Find Full Text PDFDrug Deliv Transl Res
August 2025
School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, 47500, Selangor, Malaysia.
Lipid-polymer hybrid nanoparticles (LPN) are an integration or "collaboration" between the two distinct drug delivery platforms of lipid and polymeric carriers. The idea centres on coining the advantages of both materials while attempting to overcome the limitations inherent to each component, thus improving biocompatibility, drug loading, stability, size uniformity, and controlled release properties. Since their emergence over two decades ago, LPN have attracted growing interest in various therapeutic areas such as cancer, neurological disorders, osteoarthritis, and COVID-19 viral infections.
View Article and Find Full Text PDFLangmuir
August 2025
Department of Scientific Computing, Florida State University, Tallahassee, Florida 32306, United States.
Small datasets, which are common in many traditional science and engineering disciplines, present a challenge for powerful machine learning methods that are better suited for large datasets. Through the example of spontaneous colloidal sol-gel transition, we present a data-driven framework based on Gaussian Processes (GPs) for modeling and inference with limited data. GPs are well-suited for small datasets and automatically provide uncertainty quantification for model predictions.
View Article and Find Full Text PDFPhys Rev E
April 2025
University of Edinburgh, SUPA, School of Physics and Astronomy, Edinburgh EH9 3FD, United Kingdom.
Colloidal gels formed from patchy rods provide a promising platform to design novel functional materials and formulations. Yet, the case for localized interactions at the rod tips remains relatively unexplored. Here we probe the structure and dynamics of such systems by means of coarse-grained computer simulations, and show that the emerging tipped gel networks are fundamentally different to uniform ones.
View Article and Find Full Text PDFFoods
May 2025
College of Food Science and Engineering, Shanxi Agricultural University, Jinzhong 030801, China.
The enhancement of gel properties in chicken myofibrillar proteins (MPs) is a crucial objective in meat processing. In this experiment, we systematically investigated the effects of lentinan (LNT) on MP gel formation ability and three-dimensional network structure features through multi-scale structural characterization and molecular interactions analysis and elucidated the molecular pathways of their molecular actions in regulating gel properties. The addition of LNT (0-2%, /) significantly enhanced the water-holding capacity (WHC), textural, and rheological properties of LNT-MPs.
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