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http://dx.doi.org/10.1254/fpj.144.222 | DOI Listing |
Acta Neuropathol Commun
September 2025
Department of Biomedical and Clinical Sciences and Department of Clinical Pathology, Linköping University, 58185, Linköping, Sweden.
Disruptions in synaptic transmission and plasticity are early hallmarks of Alzheimer's disease (AD). Endosomal trafficking, mediated by the retromer complex, is essential for intracellular protein sorting, including the regulation of amyloid precursor protein (APP) processing. The VPS35 subunit, a key cargo-recognition component of the retromer, has been implicated in neurodegenerative diseases, with mutations such as L625P linked to early-onset AD.
View Article and Find Full Text PDFCancer Med
September 2025
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Background: Esophageal squamous cell carcinoma (ESCC) represents an aggressive cancer type associated with poor prognosis, often treated with neoadjuvant chemotherapy (NAC) using cisplatin-based regimens. However, cisplatin resistance limits therapeutic efficacy, necessitating a deeper understanding of resistance mechanisms. L-type amino acid transporter 1 (LAT1) plays a crucial role in amino acid uptake and is linked to cancer cell survival through activation of the mammalian target of rapamycin (mTOR) pathway.
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
Ca signaling and its regulation are important for endothelial cell (EC) functions, including local blood flow control, mechanotransduction, and barrier function. Yet the spatiotemporal organization of Ca activity and its regulation across a vascular plexus is poorly understood in an mammalian context, largely due to technical barriers. To overcome this gap in knowledge, we developed an approach to resolve Ca activity with single cell resolution in the skin vasculature of live adult mice by multi-photon imaging.
View Article and Find Full Text PDFPlant Physiol
September 2025
State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Plant roots are often severed during transplanting, but plants can recover from partial root loss through compensatory growth. However, the mechanisms regulating this compensatory growth are not fully understood. Here, we showed that cutting rice (Oryza sativa L.
View Article and Find Full Text PDFJACC Basic Transl Sci
June 2025
School of Human Sciences (Physiology), The University of Western Australia, Crawley, Western Australia, Australia; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia. Electronic address:
Mitochondrial dysfunction is considered to drive the development of hypertrophic cardiomyopathy (HCM). In search of a preventative HCM therapy, we explored the efficacy of amino acid peptide variants that could alter the L-type Ca channel's regulation of mitochondrial energetics. We confirmed that 3 of the 4 variant peptides bound with high affinity to the beta subunit.
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