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Article Abstract

The DNA damage response (DDR) upregulates the expression of NKG2D ligands (NKG2DLs). We have recently reported that the DDR also induces the presence of cytosolic DNA in B-cell lymphoma cells, which leads to the activation of STING-dependent cytosolic DNA sensor pathways and the expression of RAE-1 ligands for NKG2D.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126837PMC
http://dx.doi.org/10.4161/onci.29259DOI Listing

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