Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we report that YAP1 activity is elevated in human embryonal rhabdomyosarcoma (ERMS). In mice, sustained YAP1 hyperactivity in activated, but not quiescent, satellite cells induces ERMS with high penetrance and short latency. Via its transcriptional program with TEAD1, YAP1 directly regulates several major hallmarks of ERMS. YAP1-TEAD1 upregulate pro-proliferative and oncogenic genes and maintain the ERMS differentiation block by interfering with MYOD1 and MEF2 pro-differentiation activities. Normalization of YAP1 expression reduces tumor burden in human ERMS xenografts and allows YAP1-driven ERMS to differentiate in situ. Collectively, our results identify YAP1 as a potent ERMS oncogenic driver and a promising target for differentiation therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ccr.2014.05.029 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
EXPRESS: Exacerbation of paclitaxel-induced neuropathic pain behaviors in breast tumor-bearing mice.
Mol Pain
September 2025
The Department of Pain Medicine, Division of Anesthesiology, Critical Care & Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Background: Chronic pain and cancer interact bidirectionally, with pain enhancing sensory peptides and potentially promoting tumor growth. Despite this, most chemotherapy-induced neuropathic pain (CIPN) studies overlook the contribution of cancer itself to neuropathy, focusing instead on chemotherapy-induced mechanisms. Animal models of chemotherapy-induced neuropathic pain (CINP) have been developed by injecting chemotherapeutic drugs such as paclitaxel into normal animals without cancer.
View Article and Find Full Text PDFGlial cells in the heart: Implications for their roles in health and disease.
J Physiol
September 2025
Biomedical and Life Sciences Department, Lancaster University, Lancaster, UK.
Glial cells are essential regulators of brain homeostasis by orchestrating neuronal function, metabolism and immune responses. However, much less is known about peripheral glial cells, particularly those in the heart. This review explores the development, types and functions of cardiac glial cells, including Schwann cells, satellite glial cells and recently identified cardiac nexus glia, with some reference to their central nervous system counterparts.
View Article and Find Full Text PDFUrsolic Acid from Carissa carandas L. as a Multi-Target Agent Against NSCLC: An Integrative In Silico and In Vitro Study.
J Ethnopharmacol
September 2025
P. G. Department of Biosciences, Sardar Patel University, Satellite Campus, Bakrol, Gujarat, India. Electronic address:
Ethnopharmacological Relevance: Carissa carandas L. ('Karonda'), a medicinal shrub from the Apocynaceae family, has been traditionally used in Indian ethnomedicine for the treatment of inflammation, infections, and respiratory disorders. Its phytochemically rich extracts have demonstrated diverse pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, and anticancer effects.
View Article and Find Full Text PDFDevelopmental Programming and Postnatal Modulations of Muscle Development in Ruminants.
Biology (Basel)
July 2025
Department of Animal Sciences, North Dakota State University, Fargo, ND 58105, USA.
Prenatal and postnatal skeletal muscle development in ruminants is coordinated by interactions between genetic, nutritional, epigenetic, and endocrine factors. This review focuses on the influence of maternal nutrition during gestation on fetal myogenesis, satellite cell dynamics, and myogenic regulatory factors expression, including , , and . Studies in sheep and cattle indicate that nutrient restriction or overnutrition alters muscle fiber number, the cross-sectional area, and the transcriptional regulation of myogenic genes in offspring.
View Article and Find Full Text PDFDistribution of myogenic stem cell activator, hepatocyte growth factor, in skeletal muscle extracellular matrix and effect of short-term disuse and reloading.
PLoS One
September 2025
Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.
Hepatocyte growth factor (HGF) is a key myogenic stem cell (satellite cells) activator, that resides in the extracellular matrix (ECM). However, HGF distribution in the ECM varies depending on the muscle fiber type. Furthermore, aging impedes the binding of HGF to its receptors owing to nitration by peroxynitrite (ONOO-).
View Article and Find Full Text PDF