Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113214 | PMC |
| http://dx.doi.org/10.1038/nn.3725 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Individual and Comorbid Influences of Chronic Stress and a Western Diet on Allostatic Loads and Cardiac Resilience, Adaptation and Proteome Profiles in Male Mice.
Compr Physiol
October 2025
School of Pharmacy and Medical Sciences, Griffith University, Southport, Queensland, Australia.
Mechanisms underlying cardiovascular, affective, and metabolic (CAM) multimorbidity are incompletely defined. We assessed how two risk factors-chronic stress (CS) and a Western diet (WD)-interact to influence cardiovascular function, resilience, adaptability, and allostatic load (AL); explore pathway involvement; and examine relationships with behavioral, metabolic, and systemic AL. Male C57Bl/6 mice (8 weeks old, n = 64) consumed a control (CD) or WD (12%-65%-23% or 32%-57%-11% calories from fat-carbohydrate-protein) for 17 weeks, with half subjected to 2 h daily restraint stress over the final 2 weeks (CD + CS and WD + CS).
View Article and Find Full Text PDFDifferential lipid metabolism in beef cattle: A comparative study of high and low residual feed intake bulls.
Anim Nutr
September 2025
State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
This study investigated lipid metabolism differences between low and high residual feed intake (LRFI and HRFI) bulls. Fifty-five Simmental bulls (449.84 ± 8.
View Article and Find Full Text PDFObesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons.
Res Sq
August 2025
Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center (PBRC), LSU system, Baton Rouge, LA, USA.
The preoptic area (POA) is a well-established regulator of body temperature, but its role in feeding behavior remains underexplored. Our study identifies leptin receptor (Lepr)-expressing neurons in the POA (POA) as critical component to suppress food intake (FI) and increase satiety in response to warm ambient temperatures. Utilizing chemogenetic activation in mice of both sexes, we demonstrate that selective activation of POA neurons mimics the effects of warm temperatures, leading to a significant reduction in FI.
View Article and Find Full Text PDFKCTC 15831BP-fermented industrial hempseed ( L.) supplementation corrects metabolite and gut microbiota dysbiosis, potentially mitigating Alzheimer's disease-like symptoms induced by obesity in high-fat diet-fed mice.
Food Funct
August 2025
Department of Biotechnology and Environmental Science, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea.
A long-term high-fat diet (HFD) intake causes obesity, disrupting the gut microbiota and body metabolite balance, and increasing the risk of Alzheimer's disease (AD). Fermented hempseed may restore microbiota balance, improve metabolism, and reduce neuroinflammation, potentially protecting against cognitive decline. This study investigates the protective effects and mechanisms of action of KCTC 15831BP-fermented hempseed (FHS) against AD-like symptoms induced by obesity in high-fat diet-fed mice.
View Article and Find Full Text PDFDietary-dependent sensitization of neuronal leptin signaling promotes neural repair after injury via cAMP and gene transcription.
Neuron
September 2025
Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK. Electronic address:
Dietary-dependent shifts, ranging from metabolic dysfunction to health, involve transitions in key signaling pathways. Dietary regimens can influence nervous system repair, but whether conserved, diet-specific mechanisms can enhance neuronal regeneration by directly sensitizing neuronal signaling remains unclear. We found that in mice, in contrast to a neuropathy-inducing high-fat diet that causes leptin resistance, intermittent fasting (IF) enhances leptin sensitivity in dorsal root ganglia sensory neurons.
View Article and Find Full Text PDF