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Considerable research has shown that alcohol consumption can increase aggression and produce extremes in other social behaviors. Although most theories posit that such effects are caused by pharmacological impairment of cognitive processes, recent research indicates that exposure to alcohol-related constructs, in the absence of consumption, can produce similar effects. Here we tested the hypothesis that alcohol priming is most likely to affect aggression in the context of ambiguous provocation. Experiment 1 showed that exposure to alcohol primes increased aggressive retaliation but only when an initial provocation was ambiguous; unambiguous provocation elicited highly aggressive responses regardless of prime exposure. Experiment 2 showed that alcohol prime exposure effects are relatively short-lived and that perceptions of the provocateur's hostility mediated effects of prime exposure on aggression. These findings suggest modification and extension of existing models of alcohol-induced aggression.
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http://dx.doi.org/10.1177/0146167214534993 | DOI Listing |
Environ Sci Technol
September 2025
Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck St, Boston, Massachusetts 02115, United States.
Accurate attribution of the areas and populations impacted by climate-related events often relies on linear distance-based methods, where the study unit is assigned temperature data to the closest weather station. We developed a novel method and data pipeline that provides a grid-based measure of exposure to extreme heat and cold events called Grid EXposure (, enabling linkage to individual-level human health data at different spatial scales. GridEX automates the gathering of station-based climatological data and provides estimates of apparent temperature, offering a more comprehensive representation of human thermal comfort and perceived temperature.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, 200011 Shanghai, China.
Preeclampsia (PE) is a serious complication of pregnancy characterized by chronic inflammation and immune dysregulation, which significantly increases the risk of neurodevelopmental disorders in offspring, including the autism spectrum disorder (ASD). This review investigated the potential mechanisms linking PE to ASD, with a particular focus on the role of microglial abnormalities. Epidemiological studies have revealed that prenatal exposure to PE raised the risk of ASD, with affected offspring showing increased odds ratios.
View Article and Find Full Text PDFRes Vet Sci
September 2025
Laboratorio de Genética Bioquímica LAGENBIO - Instituto de Investigación Sanitaria de Aragón (IIS) - Instituto Agroalimentario de Aragón-IA2, Universidad de Zaragoza-CITA, Zaragoza, Spain; Servicio de Cirugía y Medicina Equina, Hospital Veterinario, Universidad de Zaragoza, Zaragoza, Spain. El
The allogeneic administration of equine mesenchymal stem/stromal cells (MSCs) has numerous advantages over autologous therapy, but their interactions with the patient's immune system need to be further elucidated. These interactions can be influenced by factors such as the compatibility between donor-receptor for the major histocompatibility complex (MHC) and by the MHC expression levels, which can change under different conditions like inflammatory exposure and chondrogeneic differentiation. In this study, we evaluated the local immune response induced by chondrogeneically differentiated (MSC-chondro), pro-inflammatory primed (MSC-primed) and basal (MSC-naïve) MSCs, and how this response changes the immunomodulatory and immunogenic profiles of MSCs in vivo.
View Article and Find Full Text PDFArch Med Res
September 2025
Universidad Autónoma de Nuevo León, College of Medicine, Biochemistry and Molecular Medicine Department, Monterrey, Mexico; Universidad Autónoma de Nuevo León, Center for Research and Development in Health Sciences, Neurometabolism Unit, Monterrey, Mexico. Electronic address:
Background: Long-chain ceramides have been implicated in anxiety-like behavior and in priming microglial activation, suggesting a possible lipid-immune crosstalk in emotional regulation.
Methods: We systemically administered a mixture of C16:0, C18:0, C22:0, C24:0, and C24:1 ceramides to adult male and female mice. Anxiety-like behavior was assessed with behavioral tests.
J Biophotonics
September 2025
Laser Biomedical Applications Division, Raja Ramanna Centre for Advanced Technology, Indore, Madhya Pradesh, India.
Actin cytoskeleton alteration and cell homing/migration are crucial determinants for the success of stem cell (SC) based therapy. Photobiomodulation (PBM) is a promising non-pharmacological approach for modulating SC potency. Though ~660 nm is the most studied wavelength for the proliferation/differentiation of SCs, the migration and cytoskeleton remodeling aspects have not been investigated in detail.
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