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http://dx.doi.org/10.1167/iovs.13-13692 | DOI Listing |
Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine that acts as a central regulator of inflammation and immune responses across diverse organ systems. Functioning upstream in immune activation cascades, MIF influences macrophage polarization, T and B cell differentiation, and cytokine expression through CD74, CXCR2/4/7, and downstream signaling via NF-κB, ERK1/2, and PI3K/AKT pathways. This review provides a comprehensive analysis of MIF's mechanistic functions under both physiological and pathological conditions, highlighting its dual role as a protective mediator during acute stress and as a pro-inflammatory amplifier in chronic disease.
View Article and Find Full Text PDFVirology
August 2025
Changchun Institute of Biological Products Co.,Ltd, Changchun, China; State Key Laboratory of Novel Vaccines for Emerging Infectious Diseases, China National Biotec Group Company Limited, Beijing, China. Electronic address:
Avian influenza virus infections pose a potential pandemic threat. The currently licensed vaccines have inherent limitations, emphasizing the urgent need for improved influenza vaccines. Here, we developed a novel hemagglutinin (HA) virus-like particle (VLP) vaccine candidate through the baculovirus expression vector system (BEVS).
View Article and Find Full Text PDFArch Gerontol Geriatr
August 2025
Institute of Gerontology, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan; Institute for Future Initiatives, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:
A frailty checkup program (FC), a community-based frailty prevention initiative led by trained senior volunteers (FC supporters), has been implemented in over 100 municipalities in Japan. Participants create individual result sheets by marking blue signals for positive responses and red signals for negative responses. This cohort study aimed to examine the association between FC results and the risk of incident disability and mortality among community-dwelling older adults.
View Article and Find Full Text PDFBiochem Biophys Res Commun
August 2025
Intensive Care Unit, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei, China; Hubei Province Academy of Traditional Chinese Medicine, Wuhan, 430061, Hubei, China. Electronic address:
Background: Coxsackievirus B3 (CVB3) infection is a common cause of myocarditis, and the resulting inflammatory response and cellular damage can lead to severe cardiac dysfunction. Astragaloside IV (AS-IV), a natural compound with anti-inflammatory and antiviral properties, has shown potential therapeutic value in various inflammatory and immune-related diseases. Our study aims to explore the potential effects and underlying mechanisms of AS-IV in CVB3-induced viral myocarditis (VMC).
View Article and Find Full Text PDFJ Hazard Mater
September 2025
Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Soil and Water Conservation and Ecological Restoration of Jiangsu Province, College of Forestry & College of Soil and Water Conservation, Nanjing Forestry University, Nanjing, Jiangsu Province 210037, China.
Pollutants from industrial emissions and traffic accumulate in urban soils as road dust, carrying heavy metals (HMs) posing ecological and health risks. Magnetic susceptibility (MS), sensitive to ferromagnetic minerals, enables rapid HM contamination assessment. This study developed the Modified Dual-Threshold MS Evaluation Plot for Soil Contamination (M-Plot) using χ and χ% indices.
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