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http://dx.doi.org/10.1097/DER.0000000000000020 | DOI Listing |
Cureus
June 2025
Department of Internal Medicine, Cheikh Khalifa University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MAR.
Rowell syndrome is a rare clinical entity, defined by the association of systemic lupus erythematosus (SLE) and erythema multiforme (EM)-like skin lesions, accompanied by distinctive immunological findings such as a speckled antinuclear antibody (ANA) pattern. It predominantly affects women and requires specific diagnostic criteria. Management depends on the extent and severity of organ involvement.
View Article and Find Full Text PDFActa Dermatovenerol Croat
November 2024
Ece Gokyayla, MD, Usak Training and Research Hospital, Usak Training and Research Hospital, Usak, Turkey;
Lupus erythematosus is a multisystem disease which frequently involves the skin. There are several variants of cutaneous lupus, which are defined and classified by the location and the depth of the inflammatory infiltrate, adnexal involvement, presence or absence of interphase dermatitis, and chronology (1). The most common clinical subtypes are acute, subacute and chronic cutaneous lupus erythematosus; however, other rare specific and non-specific cutaneous involvements also exist (2).
View Article and Find Full Text PDFDermatol Online J
December 2024
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin, USA.
Enfortumab vedotin (EV) is a monoclonal antibody drug conjugate composed of antibody against nectin-4 and linked to the microtubule inhibitor monomethyl auristatin E that is used to treat metastatic urothelial carcinoma. Enfortumab vedotin-associated cutaneous adverse events are common and are clinically diverse, ranging from papulosquamous eruption to vesiculobullous eruptions such as Stevens-Johnson syndrome/toxic epidermal necrolysis and erythema multiforme-like eruption with vesiculobullae. Despite clinically diverse appearance, histopathology of EV-associated cutaneous adverse reactions often demonstrates interface dermatitis.
View Article and Find Full Text PDFEur J Dermatol
April 2025
Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Skin Health Dis
February 2025
Department of Dermatology, College of Medical Sciences Teaching Hospital, Bharatpur, Nepal.
Fixed drug eruption (FDE) is a distinct adverse drug reaction characterized by a well-defined, dusky, violaceous to erythematous patch that recurs at the same site upon re-exposure to causative drugs and resolves with hyperpigmentation. This unique reaction is a type IV hypersensitivity reaction mediated by memory CD8 T cells that reside in the basal layer of the epidermis of the resting FDE lesion. Variants of FDE described in the literature include bullous, generalized bullous, nonpigmenting, linear, papular, erythema multiforme-like, transitory giant, annular, psoriasiform, erythema dyschromicum perstans-like and cellulitis-like.
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