Sustained Efficacy and Safety of Tildrakizumab in Psoriasis Vulgaris Despite Multiple Prolonged Treatment Interruptions: A Case Report.

Psoriasis vulgaris is a persistent inflammatory skin disease that often necessitates long-term biologic therapy to maintain symptom control and prevent flares. Interruptions in biologic treatment are sometimes unavoidable due to individual health concerns or external circumstances, but the impact of repeated, extended gaps in therapy remains insufficiently understood. We describe a case involving a woman with moderate-to-severe psoriasis vulgaris who achieved sustained remission using tildrakizumab, even after multiple treatment interruptions, each lasting over a year.

Synthesis, Structures, and Properties of Dehydrobiphenyleno[12]Annulenes: Carbon-Rich Compounds Comprising Two Different Antiaromatic Units.

In this work we report the synthesis, structure, and electronic properties of carbon-rich compounds dehydrobiphenyleno[12]annulenes (DBP[12]As) comprising antiaromatic four-membered rings (4MR) and 12-membered ring (12MR). Ultraviolet-visible absorption spectra and electrochemical behaviors of DBP[12]As confirmed their relatively narrow highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap values and high HOMO energy levels, which were supported by density functional theory simulations. Parent DBP[12]A adopts a slipped herringbone structure in a crystalline state, with the molecules forming 1D stacks via π-π interactions.

Bright and water-dispersible membrane probes enable visualization of cellular morphologies and dynamics in light-scattering tissues of living mice.

Fluorescent plasma membrane probes are indispensable tools for biological studies, enabling the visualization of the fine structure and dynamics of plasma membranes, and, by extension, the overall morphology of living cells. However, their use has been mostly limited to imaging cultured cells or fixed tissue slices. Indeed, few probes have been optimized for visualizing cellular morphologies in intact tissues or organs.

Micro Crystalline Sponge Method Combined with Small-Wedge Synchrotron Crystallography for Nanogram Scale Molecular Structure Elucidation.

The crystalline sponge (CS) method enables X-ray structural analysis without the requirement of crystallization of the target compound. However, several technical and crystallographic challenges, such as low guest occupancy, static disorder, and crystal degradation, continue to limit both the accuracy and the success rate of the method. In this study, we explored the downsizing of CS crystals to the range of 1-10 μm to improve data quality and reduce the amount of sample required.

Wild-Type Transthyretin Amyloid Depositions in the Subcutaneous Fat and Skeletal Muscles of a Nonagenarian Who Had Heart Failure With Preserved Ejection Fraction and No Myocardial Technetium-99m-Labeled Pyrophosphate Uptake.

Misfolded amyloid fibrils composed of transthyretin (ATTR) cause ATTR amyloidosis, which is a systemic disease. ATTR amyloidosis can be divided into hereditary and wild-type forms according to the presence or absence of transthyretin ) gene mutations. Wild-type ATTR (ATTRwt) amyloidosis, a disease of the elderly, is more prevalent in men.

Resolution of Superimposed Linear Psoriasis With Bimekizumab After Resistance to Several Biologics.

Superimposed linear psoriasis is an uncommon form of psoriasis characterized by linear skin lesions aligned with Blaschko's lines, appearing in conjunction with typical psoriatic plaques. This variant is believed to involve cutaneous mosaicism and often shows differential treatment responses between linear and conventional lesions. We present the first case of superimposed linear psoriasis that was resistant to several biologic agents but responded favorably to bimekizumab, a monoclonal antibody targeting both interleukin (IL)-17A and IL-17F.

Horizontal Imaging of Skin Tumors Using Advanced Fluorescence Techniques for Detecting Individual Malignant Cells.

Conventional histopathological techniques, such as hematoxylin and eosin staining, are limited to 4-5 μm-thick tissue sections, restricting visualization to two-dimensional planes. Moreover, acquisition of three-dimensional horizontal images from the skin surface remains challenging, hindering precise assessment of tumor margins in skin lesions. This challenge is particularly pronounced in extramammary Paget's disease (EMPD), in which diffuse epidermal tumor cell spread complicates accurate evaluation of lesion extent.

A case of anti-SAE antibody-positive dermatomyositis presenting with preceding panniculitis as the initial symptom.

Myositis-specific autoantibodies found in dermatomyositis (DM) are associated with clinical symptoms and responses to therapy and are useful for diagnosis, treatment selection, and prognostication. Although the prevalence of anti-small ubiquitin-like modifier-activating enzyme (anti-SAE) antibodies in DM patients is low, clinical features such as skin symptoms preceding muscle symptoms and a higher incidence of dysphagia and malignancy have been reported. Herein, we present a case of anti-SAE antibody-positive DM in which panniculitis of the lower legs, a rare dermatological manifestation of DM, preceded muscle symptoms by 2 months.

Permutation-based global rank test with adaptive weights for multiple primary endpoints.

Multiple efficacy endpoints are investigated in clinical trials, and selecting the appropriate primary endpoints is key to the study's success. The global test is an analysis approach that can handle multiple endpoints without multiplicity adjustment. This test, which aggregates the statistics from multiple primary endpoints into a single statistic using weights for the statistical comparison, has been gaining increasing attention.

Host-Guest Chemistry in a Capillary Applied to the Facilitation of the Crystalline Sponge Method.

Capillary is a handy tool for transferring, mixing, and storing small volumes of liquid. Here, we show that the stepwise dipping of host and guest solutions into a capillary allows efficient preparation, crystallization, and X-ray analysis of various host-guest complexes. The crystals formed in capillaries are comparable in quality to those grown in regular flasks and subjected to X-ray analysis without being removed from the capillary.

Streamlined modular synthesis of saframycin substructure via copper-catalyzed three-component assembly and gold-promoted 6- cyclization.

The integration of copper(I)-catalyzed three-component coupling with gold(I)-mediated 6- cyclization streamlines the rapid and modular assembly of the substructure of bis-tetrahydroisoquinoline (THIQ) alkaloids. The design of the key synthetic intermediate bearing a 2,3-diaminobenzofuran moiety allows both gold(I)-mediated regiocontrolled 6- hydroamination and temporary protection of nitrile and phenolic hydroxy groups. The synthetic strategy enabled the efficient synthesis of the substructure of saframycins bearing isoquinoline and THIQ units in just four steps from the modular assembly of the three components.

Characterization of Diploid Wheat Flour and its Possible Practical Use.

The application of flour is determined by the composition of its starch and storage proteins. Previously isolated diploid wheat is known to be amylose-free and possesses the same amylopectin structure as the wild-type. To reveal its characteristics, starch, protein, lipid, fiber, gluten, and allergen contents and rheological properties were analyzed and compared to its parental wild-type diploid wheat and commercially available hexaploid wheats.

Survivability and life support in sealed mini-ecosystems with simulated planetary soils.

Establishing a sustainable life-support system for space exploration is a formidable challenge due to the vast distances, high costs, and environmental differences from Earth. Building upon the lessons from the Biosphere 2 experiment, we introduce the novel "Ecosphere" and "Biosealed" systems, self-sustaining ecosystems within customizable, enclosed containers. These systems incorporate terrestrial ecosystems and groundwater layers, offering a potential model for transplanting Earth-like biomes to extraterrestrial environments.

Molecular cylinders with donor-acceptor structure and swinging motion.

The construction of three-dimensional nanocarbon structures with well-defined molecular dynamics is a challenging yet rewarding task in material science and supramolecular chemistry. Herein, we report the synthesis of two highly defective, nitrogen-doped molecular cylinders, namely MC1 and MC2, with a length of 1.4 nm and 2.