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The objective of this study was to investigate the dose enhancement to soft tissue due to backscatter radiation near metal interfaces during head and neck radiotherapy. The influence of titanium-mandibular plate with the screws on radiation dose was tested on four real bones from mandible with the metal and screws fixed. Radiochromic films were used for dosimetry. The bone and metal were inserted through the film at the center symmetrically. This was then placed in a small jig (7 cm × 7 cm × 10 cm) to hold the film vertically straight. The polymer granules (tissue-equivalent) were placed around the film for homogeneous scatter medium. The film was irradiated with 6 MV X-rays for 200 monitor units in Trilogy linear accelerator for 10 cm × 10 cm field size with source to axis distance of 100 cm at 5 cm. A single film was also irradiated without any bone and metal interface for reference data. The absolute dose and the vertical dose profile were measured from the film. There was 10% dose enhancement due to the backscatter radiation just adjacent to the metal-bone interface for all the materials. The extent of the backscatter effect was up to 4 mm. There is significant higher dose enhancement in the soft tissue/skin due to the backscatter radiation from the metallic components in the treatment region.
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http://dx.doi.org/10.4103/0971-6203.125501 | DOI Listing |
Wounds
August 2025
Department of Day Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China; China International Science and Technology Coopera
Background: Current management of pediatric cutaneous abscesses involves either spontaneous healing by secondary intention or suturing through tertiary intention, which are often lengthy processes that cause discomfort and distress among children. As it is noninvasive and simple, a novel zipper device is widely used for the primary wound closure of surgical incisions.
Objective: To describe the effectiveness of novel zipper device use for pediatric cutaneous abscess wound closure in an outpatient context.
Fundam Clin Pharmacol
October 2025
Postgraduate Program in Pharmaceutical Science, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
This review highlights the integration of drug repurposing and nanotechnology-driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application. The rising prevalence of antifungal resistance and virulence factors of Candida albicans underscore the limitations of current therapies. Statins, commonly used as lipid-lowering agents, have emerged as attractive repurposed drug candidates due to their ability to interfere with fungal ergosterol biosynthesis and Ras-mediated signaling pathways.
View Article and Find Full Text PDFEnviron Monit Assess
September 2025
College of Ecological and Environmental Engineering, Guizhou Minzu University, Guiyang, 550025, China.
The rapid development of industry and agriculture has led to a significant increase in the toxicity and pollution of cadmium (Cd) and lead (Pb) in soil. Consequently, soil remediation employing biochar or modified biochar has emerged as a cost-effective and environmentally sustainable approach to address the issue of heavy metal (HM) ion pollution. PEI-functionalization biochar (PBC) derived from corn straw (PBCC), wood straw (PBCW), and rice straw (PBCR) was synthesized to immobilize Cd and Pb in contaminated acidic yellow soil.
View Article and Find Full Text PDFJ Neurointerv Surg
September 2025
Cerebrovascular and Neuro-Intervention Department, Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
Background: Remote live-streamed training in endovascular thrombectomy (EVT) is a novel educational strategy. This study evaluated the dose-response relationship between training duration and clinical outcomes, and explored mediation pathways.
Methods: In a prospective cohort study, 1046 participants received remote EVT training, with 1010 completing follow-up.
Neuropharmacology
September 2025
University of Nebraska-Lincoln, Department of Psychology, 238 Burnett Hall, Lincoln, NE 68588.
Hormonal contraceptives containing a synthetic estrogen (e.g., ethinyl estradiol/EE) and/or a progestin (e.
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