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Article Abstract
Use of new compound such as inhibitors of JAK2 or transforming growth factor β-like molecules might soon revolutionize the treatment of β-thalassemia and related disorders. However, this situation requires careful optimization, noting the potential for off-target immune suppression for JAK2 inhibitors and the lack of mechanistic insights for the use of the ligand trap soluble molecules that sequester ligands of activin receptor IIA and B.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970239 | PMC |
| http://dx.doi.org/10.1016/j.hoc.2013.12.001 | DOI Listing |
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