3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs.

Adv Mater

School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, 02138, USA.

Published: May 2014


Article Synopsis

  • A novel bioprinting technique allows for the creation of complex 3D tissue structures that include blood vessels, various cell types, and extracellular matrix.
  • The process involves co-printing different materials, referred to as bioinks, to accurately build these intricate constructs.
  • This advancement in 3D tissue fabrication has significant implications for drug testing and research on wound healing, blood vessel formation, and stem-cell environments.

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Article Abstract

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.

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http://dx.doi.org/10.1002/adma.201305506DOI Listing

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