Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Numerous studies establish associations between adverse perinatal outcomes/complications and autism spectrum disorder (ASD). There has been little assessment of population attributable fractions (PAFs).
Methods: We estimated average ASD PAFs for preterm birth (PTB), small for gestational age (SGA), and Cesarean delivery (CD) in a U.S. population. Average PAF methodology accounts for risk factor co-occurrence. ASD cases were singleton non-Hispanic white, non-Hispanic black, and Hispanic children born in 1994 (n = 703) or 2000 (n = 1339) who resided in 48 U.S. counties included within eight Autism and Developmental Disabilities Monitoring Network sites. Cases were matched on birth year, sex, and maternal county of residence, race-ethnicity, age, and education to 20 controls from U.S. natality files.
Results: For the 1994 cohort, average PAFs were 4.2%, 0.9%, and 7.9% for PTB, SGA, and CD, respectively. The summary PAF was 13.0% (1.7%-19.5%). For the 2000 cohort, average PAFs were 2.0%, 3.1%, and 6.7% for PTB, SGA, and CD, respectively, with a summary PAF of 11.8% (7.5%-15.9%).
Conclusions: Three perinatal risk factors notably contribute to ASD risk in a U.S. population. Because each factor represents multiple etiologic pathways, PAF estimates are best interpreted as the proportion of ASD attributable to having a suboptimal perinatal environment resulting in PTB, SGA, and/or CD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562459 | PMC |
| http://dx.doi.org/10.1016/j.annepidem.2013.12.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Risks of prematurity and low birth weight associated with trimester-specific prenatal benzodiazepine exposure.
J Psychiatry Neurosci
August 2025
From the Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (V.C.-H. Chen); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (V.C.-H. Chen); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Psychology, A
Background: Intrauterine exposure of the developing fetus or neonate to bendodiazepine may lead to fetal abnormalities or adverse reactions. We sought to investigate whether benzodiazepine use before or during different trimesters of pregnancy had different associations with incident preterm births (PTB) or small for gestational age (SGA) infants.
Methods: We conducted a 13-year longitudinal cohort study incorporating population-wide, sibling, and paternal comparisons.
A study on the correlation between pregnancy risk factors and birth outcomes.
Sci Rep
August 2025
Liaoning Maternal and Child Health Hospital, Shenyang, Liaoning, China.
Adverse birth outcomes-including low birth weight (LBW, < 2500 g), preterm birth (PTB, < 37 weeks), and intrauterine growth abnormalities-remain major global public health challenges, particularly in low- and middle-income countries. Although maternal body mass index (BMI) and gestational weight gain (GWG) are established risk factors in Western populations, their interactions with metabolic and sociodemographic factors in Asian cohorts, particularly within China's rapidly urbanizing populations, warrant further investigation. This prospective cohort study analyzed 1,026,294 singleton pregnancies (2012-2018) from the Liaoning Maternal and Child Health Information System.
View Article and Find Full Text PDFTrends in adverse perinatal outcomes and associated hospitalisations, emergency department presentations, and healthcare costs from birth to early childhood in the Northern Territory, Australia: A two-decade population-based study.
PLOS Glob Public Health
August 2025
Curtin School of Population Health, Curtin University, Perth, Western Australia, Australia.
Adverse perinatal outcomes, including preterm birth (PTB), small-for-gestational-age (SGA), and low birthweight (LBW), impact childhood health and impose substantial burdens. This retrospective cohort study included all births in the Northern Territory, Australia, from July 1, 2000, to June 30, 2016, examining trends in these outcomes and related hospitalisations, emergency department (ED) presentations, and healthcare costs through June 30, 2021. Births were linked to hospitalisation, ED, and cost-weight data.
View Article and Find Full Text PDFAssociations between antenatal organophosphate pesticide exposure and pregnancy outcomes: The Japan Environment and Children's Study (JECS).
Sci Total Environ
August 2025
Department of Social Medicine, Graduate School of Medicine, The University of Osaka, Yamadaoka 2-2, Suita, Osaka 565-0871, Japan; Institute for Global Health Policy Research, Bureau of International Health Cooperation, Japan Institute for Health Security, Toyama 1-21-1, Shinjuku-ku, Tokyo 162-8655,
To examine the association between antenatal exposure to organophosphate (OP) pesticides, measured using urinary dialkyl phosphate (DAP) metabolite concentrations, and pregnancy outcomes in Japan's large nationwide birth cohort. We included 4444 pregnant women from the Japan Environment and Children's Study (JECS). Urinary concentrations of six DAP metabolites during the first trimester were measured.
View Article and Find Full Text PDFAnalysis on the prevalence and temporal trends of adverse birth outcomes among neonates in Shanghai from 2010 to 2023.
Front Public Health
August 2025
Department of Chronic Non-communicable Disease Control, YangPu District Center for Disease Control and Prevention, Shanghai, China.
Background: Previous research has focused on the risk factors of adverse birth outcomes and its short-term and long-term consequences. However, study on the temporal trends of adverse birth outcomes is few. Furthermore, the population-level correlation between the rate of advanced maternal age (AMA) and the prevalence of adverse birth outcomes remains underexplored.
View Article and Find Full Text PDF