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The round window region is a critical area of the middle ear; the aim of this paper is to describe its anatomy from an endoscopic perspective, emphasizing some structures, the knowledge of which could have important implications during surgery, as well as to evaluate what involvement cholesteatoma may have with these structures. Retrospective review of video recordings of endoscopic ear surgeries and retrospective database review were conducted in Tertiary university referral center. Videos from endoscopic middle ear procedures carried out between June 2010 and September 2012 and stored in a shared database were reviewed retrospectively. Surgeries in which an endoscopic magnification of the round window region and the inferior retrotympanum area was performed intraoperatively were included in the study. Involvement by cholesteatoma of those regions was also documented based on information obtained from the surgical database. Conformation of the tegmen of the round window niche may influence the surgical view of round window membrane. A structure connecting the round window area to the petrous apex, named the subcochlear canaliculus, is described. Cholesteatoma can invade the round window areas in some patients. Endoscopic approaches can guarantee a very detailed view and allow the exploration of the round window region. Exact anatomical knowledge of this region can have important advantages during surgery, since some pathology can invade inside cavities or tunnels otherwise not seen by instrumentation that produces a straight-line view (e.g. microscope).
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http://dx.doi.org/10.1007/s00405-014-2923-8 | DOI Listing |
Neurotoxicology
September 2025
Department of Otolaryngology Head and Neck Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China. Electronic address:
Gadolinium-based contrast agents (GBCAs) are widely used in systemic magnetic resonance imaging (MRI) and can be employed in otology to evaluate endolymphatic hydrops in patients with Ménière's disease. Given the heavy metal properties of gadolinium and its tendency to deposit in tissues, it is essential to assess its ototoxic risk. We evaluated the ototoxicity of gadodiamide using in vitro and in vivo models.
View Article and Find Full Text PDFEur J Pharm Sci
September 2025
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:
Intratympanic (IT) delivery of dexamethasone (DEX) is widely used for treating inner ear disorders; however, its therapeutic efficacy is limited by poor permeability of the round window membrane (RWM). This study aimed to evaluate and compare the efficacy and safety of three pharmacological agents-histamine (HIS), 3% hypertonic saline (3% HS), and sodium caprate (SC)-as adjuvants for enhancing RWM permeability and improving IT-DEX delivery in a murine model. Following IT administration of each permeability enhancer followed by DEX injection, perilymph DEX concentrations were measured using ultra-high-performance liquid chromatography, and DEX receptor expression in the organ of Corti was assessed by immunofluorescence.
View Article and Find Full Text PDFOtol Neurotol
August 2025
Department of Radiology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Objective: To investigate the anatomical diversity of the round window (RW) in the pediatric population, focusing on its transcanal trajectory and anatomical angles. The study aims to provide insights into how RW accessibility changes with age, which may impact surgical planning and drug delivery approaches.
Study Design: Retrospective radiologic review of pediatric patients who underwent high-resolution CT scans of the temporal bone.
BMC Vet Res
September 2025
Department of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, Prague Suchdol, 165 00, Czech Republic.
Background: Pathogenic blood-feeding nematodes, such as Haemonchus contortus and the invasive Ashworthius sidemi, infect a wide range of wild and domestic ruminants. While the spread of A. sidemi among European cervids has been studied, its presence in chamois (Rupicapra rupicapra) remains poorly documented.
View Article and Find Full Text PDFInt J Biol Macromol
August 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany; Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), Hannover Medical School, Hannover, Germany; Cluster of Excellence "Hearing4all", German Research Foundation,
The anatomical and structural complexity and variability of the hearing organ pose significant challenges for efficient drug delivery to treat inner ear disorders. To address this issue, we developed a local drug delivery implant (LDDI) fabricated with 3D printing technology. The implant is personalized based on the individual patient's anatomy of the round window niche from where drugs can diffuse into the inner ear.
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