Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Isolated sinus of Valsalva (SV) aneurysm is a rare condition that may arise in patients with congenital ventricular septal defects (VSD). Small VSDs are often left untreated because of high rate of spontaneous closure. However, complications such as aortic regurgitation and infective endocarditis may occur as complications of small VSDs. We present the case of a 19-year-old man with a history of VSD, who presented with Staphylococcus aureus endocarditis and a contained rupture of the SV into the right ventricle, which was successfully treated. In the light of this case, we believe that even small VSDs should be assessed regularly and treated before such drastic complications occur.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/2150135112474025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Atomistic simulation of voltage activation of a truncated BK channel.
Elife
September 2025
Department of Chemistry, University of Massachusetts, Amherst, United States.
Voltage-dependence gating of ion channels underlies numerous physiological and pathophysiological processes, and disruption of normal voltage gating is the cause of many channelopathies. Here, long timescale atomistic simulations were performed to directly probe voltage-induced gating transitions of the big potassium (BK) channels, where the voltage sensor domain (VSD) movement has been suggested to be distinct from that of canonical Kv channels but remains poorly understood. Using a Core-MT construct without the gating ring, multiple voltage activation transitions were observed at 750 mV, allowing detailed analysis of the activated state of BK VSD and key mechanistic features.
View Article and Find Full Text PDFTranscatheter Repair of Ventricular Septal Defect Post Myocardial Infarction at a Community Hospital: A Case Study.
Cureus
July 2025
Anesthesiology, Providence Santa Rosa Memorial Hospital, Santa Rosa, USA.
Ventricular septal defect (VSD) is a rare complication following a myocardial infarction (MI), with a very high mortality rate if left untreated. Traditionally, surgical repair has been used to treat VSDs, but even in those cases, it has poor outcomes. This case shows a middle-aged woman who suffered an MI complicated by a VSD successfully treated with a transcatheter approach to repair the defect.
View Article and Find Full Text PDFPerventricular Device Closure of Native Congenital Muscular Ventricular Septal Defects in Small Infants ≤ 5 kg: Single-Center Study of the Risk Factors for Failure of the Intervention and Non-Optimal Outcome.
Catheter Cardiovasc Interv
July 2025
Department of Pediatric Cardiology, Dr. Siyami Ersek Training and Research Hospital for Cardiology and Cardiovascular Surgery, İstanbul, Turkey.
Background And Aims: Perventricular device closure of muscular VSD in small infants is a less invasive option than surgical closure under cardiopulmonary bypass and offers better outcomes than palliative pulmonary artery banding. However, the specific risk factors that could affect procedural success and optimal outcomes have not been comprehensively examined in prior studies. The aim of this study is to analyze the risk factors for procedural failure and nonoptimal outcome in perventricular device closure of muscular VSD.
View Article and Find Full Text PDFSuper-resolution deep learning in pediatric CTA for congenital heart disease: enhancing intracardiac visualization under free-breathing conditions.
Eur Radiol
July 2025
Department of Radiology, Kunming Yan'an Hospital (Yan'an Hospital Affiliated to Kunming Medical University), Kunming, China.
Objective: This study assesses the effectiveness of super-resolution deep learning reconstruction (SR-DLR), conventional deep learning reconstruction (C-DLR), and hybrid iterative reconstruction (HIR) in enhancing image quality and diagnostic performance for pediatric congenital heart disease (CHD) in CT angiography (CCTA).
Materials And Methods: A total of 91 pediatric patients aged 1-10 years, suspected of having CHD, were consecutively enrolled for CCTA under free-breathing conditions. Reconstructions were performed using SR-DLR, C-DLR, and HIR algorithms.
Atomistic Simulation of Voltage Activation of a Truncated BK Channel.
bioRxiv
June 2025
Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
Voltage-dependence gating of ion channels underlies numerous physiological and pathophysiological processes, and disruption of normal voltage gating is the cause of many channelopathies. Here, long timescale atomistic simulations were performed to directly probe voltage-induced gating transitions of the big potassium (BK) channels, where the voltage sensor domain (VSD) movement has been suggested to be distinct from that of canonical Kv channels but remains poorly understood. Using a Core-MT construct without the gating ring, multiple voltage activation transitions were observed at 750 mV, allowing detailed analysis of the activated state of BK VSD and key mechanistic features.
View Article and Find Full Text PDF