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Background: To examine the effects of physical activity on the development and progression of microvascular complications in patients with type 1 diabetes.
Methods: A retrospective analysis of data from the Diabetes Control and Complications trial was undertaken. Physical activity data was collected at baseline for each of 1441 recruits, converted to metabolic equivalent of task values, and categorised according to the American College of Sports Medicine recommendations. The rates of development/progression of diabetic retinopathy, nephropathy and neuropathy were compared in those who achieved over twice recommended, up to twice recommended, and less than recommended metabolic equivalent of task levels of activity. The DCCT study had a mean duration of follow up of 6.5 years ending in 1993.
Results: A total of 271 subjects had a sustained three-step progression in diabetic retinopathy. The rates of development or progression of retinopathy showed no significant association with physical activity level. The number of outcomes for nephropathy and neuropathy were small and there was no significant association with physical activity level.
Conclusions: We found no evidence that physical activity improves microvascular outcomes in type 1 diabetes. However we demonstrate no evidence of harm. We suggest that physical activity continues to play an important role in the management of type 1 diabetes.
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http://dx.doi.org/10.1186/1472-6823-13-37 | DOI Listing |
Turk J Pediatr
September 2025
Department of Cardiorespiratory Physiotherapy and Rehabilitation, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Türkiye.
Background: Vascular changes are observed in children with cystic fibrosis (cwCF), and gender-specific differences may impact arterial stiffness. We aimed to compare arterial stiffness and clinical parameters based on gender in cwCF and to determine the factors affecting arterial stiffness in cwCF.
Methods: Fifty-eight cwCF were included.
Turk J Pediatr
September 2025
Department of Pediatrics, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Türkiye.
Background: With the development of technology, easier access to the internet and its excessive use have led to problematic internet use (PIU). The prevalence of PIU and its association with lifestyle behaviors in adolescents have become subjects of increasing academic interest. This study aimed to determine the prevalence of PIU among Turkish high school students and to investigate its association with sleep, physical activity and dietary habits.
View Article and Find Full Text PDFCuad Bioet
September 2025
Universidad Católica de Murcia. Observatorio de Bioética de la Universidad Católica de Valencia. Carlos Albors, 34. 46220 Picassent
Although, in principle, the Lancet article Commission on Medicine, Nazism, and the Holocaust, aims to provide medical students with a moral compass to guide the future of medical practice as a social retaining wall against anti-Semitism, it deals with the Holocaust not from a philosophical point of view, but from a pedagogical one, resorting to didactic strategies from a historiographical approach. What seemed to be a plea against the behaviour of the Nazi doctors' experiments becomes a justification of the positive law of the liberal democracies in use. However, what it ignores is of the utmost importance: that the majority of the regime's doctors were tried and sentenced for their iniquitous actions, and yet, in contemporary Western society, an even greater danger is very much present: techno-science, which, as it stands, can once again compromise the identity, dignity and very life of the human person.
View Article and Find Full Text PDFJ Exp Anal Behav
September 2025
Fralin Biomedical Research Institute at VTC, Roanoke, VA, United States of America.
Reward delays are often associated with reduced probability of reward, although standard assessments of delay discounting do not specify degree of reward certainty. Thus, the extent to which estimates of delay discounting are influenced by uncontrolled variance in perceived reward certainty remains unclear. Here we examine 370 participants who were randomly assigned to complete a delay discounting task when reward certainty was either unspecified (n=184) or specified as 100% (n = 186) in the task trials and task instructions.
View Article and Find Full Text PDFPLoS One
September 2025
School of Electrical and Information Engineering, Hunan Institute of Technology, Hengyang, Hunan, China.
Knowledge tracing can reveal students' level of knowledge in relation to their learning performance. Recently, plenty of machine learning algorithms have been proposed to exploit to implement knowledge tracing and have achieved promising outcomes. However, most of the previous approaches were unable to cope with long sequence time-series prediction, which is more valuable than short sequence prediction that is extensively utilized in current knowledge-tracing studies.
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