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A biomimetic energy converter was fabricated via the assembly of CF0F1-ATPase on lipid-coated hollow nanocapsules composed of α-cyclodextrins/chitosan-graft-poly(ethylene glycol) methacrylate. Upon entrapped GOD into these capsules, the addition of glucose could trigger proton-motive force and then drive the rotation of ATPase to synthesize ATP.
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http://dx.doi.org/10.1021/bm400584h | DOI Listing |
Carbohydr Polym
November 2025
School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Haiquan Road, Shanghai 201418, China. Electronic address:
Food flavors and fragrances are vital for foods. They can impart aroma and flavor to foods, enhance and compensate for flavor perception of foods, and mask the undesirable flavor of foods, thus increasing overall food acceptability and consumers' purchase intention. However, most of the flavors and fragrances are sensitive to air, moisture, heat, and light, leading to difficulties in processing them and adding them to foods.
View Article and Find Full Text PDFHeliyon
November 2024
Department of Chemistry, Bangladesh University of Engineering and Technology (BUET), Dhaka, 1000, Bangladesh.
This article discusses and summarizes some fascinating outcomes and applications of cyclodextrins (CDs) and their derivatives in drug delivery. These applications include the administration of protein, peptide medications, and gene delivery. Several innovative drug delivery systems, including NPs, microspheres, microcapsules, and liposomes, are designed with the help of CD, which is highlighted in this article.
View Article and Find Full Text PDFCarbohydr Polym
February 2022
College of Food Science and Technology, Bohai University, Jinzhou 121013, PR China. Electronic address:
The present study focused on the integration of beta-cyclodextrin based metal-organic frameworks (β-CDMOF) with polymer to obtain hybrid materials with advantageous properties compared to traditional single-component polymers or metal-organic frameworks (MOF) matrixes. We fabricated two complexes with different morphology and structure. During the in situ growth of β-CDMOF around the hydrogel, potassium ions on polysaccharides gradually dissociated to participate in the growth of crystals, while other potassium ions on the carboxylic acid groups provided bridges between crystals and hydrogel, forming a necklace-shaped complex (SHPs@β-CDMOF).
View Article and Find Full Text PDFRecent Pat Nanotechnol
May 2020
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, India.
Background: Currently, the most important challenge in the development of therapeutics and actives is their poor aqueous solubility and bioavailability.
Objective: The low aqueous solubility, poor pharmacokinetic properties, and bioavailability associated with novel actives manifest in numerous challenges in the formulation of conventional dosage forms like tablets, capsules, suspensions, emulsions, etc. Nanosponges are a novel class of drug delivery system capable of encapsulating or entrapping both lipophilic and hydrophilic drugs.
Int J Pharm
June 2017
Drug Delivery and Disposition, KU Leuven, Gasthuisberg O&N II, Herestraat 49 - Box 921, 3000 Leuven, Belgium. Electronic address:
This study evaluated the fasted state gastrointestinal behavior of the lipophilic drug itraconazole, orally administered to healthy volunteers as either a solid dispersion (Sporanox capsules) or a cyclodextrin-based solution (Sporanox solution). Following intake of the drug products, gastric and duodenal fluids were aspirated and analyzed for itraconazole concentration, total content and solubilizing capacity. Release of itraconazole from the solid dispersion generated high and metastable supersaturated levels in the stomach, but the dissolved fraction in the duodenum remained extremely low (median 2.
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