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Cell or vesicle adhesion plays an essential role in a plethora of physiological activities. In this study, we established a theoretical model to explore the adhesion behavior of a vesicle adhering on an elastic substrate. Based upon the free energy functional of the system, the governing equation set and the transversality boundary conditions were derived. The morphology of the vesicle-substrate system and the phase diagram were presented, and it was found that there exist different wrapping states depending on the work of adhesion and bending stiffness. Finally, the adhesion behavior of a vesicle to a rigid substrate was investigated. These analyses are beneficial to understanding the mechanism of cell motility, and cast a new light on the droplet wrapped by a membrane when input the voltage.
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http://dx.doi.org/10.1016/j.colsurfb.2013.05.004 | DOI Listing |
Langmuir
September 2025
Process Engineering in Life Science Engineering, HTW Berlin, Wilhelminenhofstraße 75 A, 12459 Berlin, Germany.
Pickering emulsions (PEs), where water-in-oil (w/o) droplets are stabilized by nanoparticles (NPs), offer a promising platform for biocatalysis by providing a large interfacial area crucial for efficient substrate conversion. While several lipase catalyzed reactions in PEs have been demonstrated, the exact interfacial structure is unknown. This study focuses on the interfacial network formed by NPs and lipase (CRL) at the octanol/water-interface by varying pH and NP charge.
View Article and Find Full Text PDFACS Omega
September 2025
Materials and Manufacturing Directorate, AFRL/RXEE, Air Force Research Laboratory, Wright-Patterson AFB, Ohio 45433, United States.
This study addresses a critical limitation in direct bonded copper (DBC) materials used in power electronics by introducing a copper-zirconium (Cu/Zr) alloy interposing layer at the copper-ceramic interface. This novel design aims to mitigate mechanical stress induced by mismatched material properties, such as the coefficient of thermal expansion (CTE) and elastic modulus, during thermal cycling. The key findings of this study are (1) thermal fatigue improvement: Test samples with the Cu/Zr interface layer (Cu-Cu/Zr-AlN) three times enhanced thermal fatigue resistance, surviving 30 thermal cycles from -55 to 300 °C before delamination, while standard DBC substrates without the Cu/Zr layer failed after just 10 cycles, indicating a performance improvement with the Cu/Zr alloy, (2) durability projections: Based on the Coffin-Manson model, if the upper temperature is capped at 150 °C, the Cu-Cu/Zr-AlN substrates are projected to survive approximately 1372 cycles, underscoring their potential for long-term reliability, and (3) stress mitigation: The Cu/Zr alloy layer bridges the CTE disparity between copper and ceramic, reducing mechanical stress and improving structural integrity across a broad temperature range (-55 to 300 °C).
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
August 2025
School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacturing of Precision Medicine Equipment, Southeast University, Nanjing, 211189, China. Electronic address:
Poly(L-lactic acid) (PLLA), as a substrate material, has been widely utilized in the field of biodegradable vascular stents. Prior to implantation, it is particularly crucial for these devices to assess the relationship of the mechanical properties and microstructures during full degradation cycle. Although previous studies have primarily focused on structural parameters such as crystallinity and molecular weight, there are relatively few reports that explore the impact of microstructure on mechanical performance from the perspective of chain configuration during the degradation.
View Article and Find Full Text PDFInt J Biol Macromol
August 2025
Key Laboratory for the Structure and Function of Polysaccharides in Traditional Chinese Medicine (Administration of Traditional Chinese Medicine of Jilin Province), Beihua University, Jilin 132013, China. Electronic address:
This study proposes a method for producing quaternized chitosan and genipin cross-linked hydrogels with adjustable mechanical properties to promote cell proliferation and, in turn, enhance skin repair. In this method, tannic acid at varying volume fractions is added to the quaternized chitosan and base-catalyzed crosslinked polymer dispersion system, forming hydrogels with different elastic moduli. The mechanical properties of the hydrogels are characterized using a rheometer and a universal testing machine.
View Article and Find Full Text PDFAdv Mater Technol
July 2025
Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221.
This study investigates bioelectric stimulation's role in tissue regeneration by enhancing the piezoelectric properties of tissue-engineered grafts using annealed poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) scaffolds. Annealing at temperatures of 80°C, 100°C, 120°C, and 140°C is assessed for its impact on material properties and physiological utility. Analytical techniques such as Differential Scanning Calorimetry (DSC), Fourier-Transform Infrared Spectroscopy (FTIR), and X-ray Diffraction (XRD) reveal increased crystallinity with higher annealing temperatures, peaking in β-phase content and crystallinity at 140°C.
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