Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC50 values in the range 0.60-0.78 μM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np300792t | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lipoxygenase Inhibitor From Endophytic Fungus Cladosporium ramotenellum Associated With Argemone mexicana L.
Chem Biodivers
September 2025
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India.
Argemone mexicana is one of the known herbaceous plants hosting bioactive isoquinoline alkaloids. In the current study, an endophytic fungal isolate was studied for anti-inflammatory potential and the identification of its bioactive molecule. An endophytic fungus AMEF-14 was obtained from this plant and identified as Cladosporium ramotenellum based on microscopy and molecular tools.
View Article and Find Full Text PDFTranscriptomics analysis for elucidating the mechanism underlying the enhancement of Arabidopsis Thaliana growth by the endophytic fungus Clonostachys rosea.
Arch Microbiol
September 2025
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Endophytic fungi are nonpathogenic fungi that live symbiotically in the interior of healthy plant tissues and form mutualistic associations with their hosts. These fungi are critically involved in promoting plant development, strengthening plant uptake of nutrients, and improving plant resistance to biotic and abiotic stress conditions. Endophytic fungi improve plant growth by synthesizing phytohormones (e.
View Article and Find Full Text PDFEndophytic Fusarium isolates from Ceratozamia mirandae enhance tomato growth, suppress pathogenic fungi, and induce protection against Botrytis cinerea.
Rev Argent Microbiol
September 2025
IPICYT, División de Biología Molecular, Laboratorio de Genómica Funcional y Comparativa, Camino a la Presa San José 2055, Col. Lomas 4 Sección, 78216 San Luis Potosí, SLP, Mexico.
Fungal diseases in agricultural crops cause economic losses, with chemical control being the conventional method to manage them. However, this approach negatively impacts both the environment and human health. This study focused on endophytic fungi isolated from the roots of Ceratozamia mirandae in the Mexican locality of Juan Sabines (Villa Corzo, Chiapas).
View Article and Find Full Text PDFPhenotypic, Chemotaxonomic, and Genome-Based Classification of Strains: Two Proposed Novel Species, sp. nov. and sp. nov.
Biology (Basel)
August 2025
Department of Genetics and Microbiology, Maria Curie-Sklodowska University, Akademicka 19 Str., 20-033 Lublin, Poland.
The taxonomic status of two bacterial strains, KW56 and 2063, isolated from root nodules of (Spanish broom), was investigated using a polyphasic approach. Both isolates belong to the genus , yet exhibit significant genotypic and phenotypic differences from all currently described species. Whole-genome comparisons revealed that strain KW56 is most closely related to PETP 02, while strain 2063 is related to strains STM 196 and 29-15.
View Article and Find Full Text PDFEco-Friendly Silver Nanoparticles Synthesis Method Using Medicinal Plant Fungal Endophytes-Biological Activities and Molecular Docking Analyses.
Biology (Basel)
July 2025
Cosmetics and Natural Product Research Center (CosNat), Department of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
The integration of nanotechnology and green synthesis strategies provides innovative solutions in biomedicine. This study focuses on the biofabrication of silver nanoparticles (AgNPs) using , an endophytic fungus isolated from . The eco-friendly synthesis process employed fungal extracts as reducing and stabilizing agents thereby minimizing the need for hazardous chemicals.
View Article and Find Full Text PDF