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Study Design: Within-subject, repeated-measures design.
Objectives: To measure tibiofemoral contact forces during cycling in vivo and to quantify the influences of power, pedaling cadence, and seat height on tibiofemoral contact forces.
Background: Cycling is usually classified as a low-demand activity for the knee joint and is therefore recommended for persons with osteoarthritis and rehabilitation programs following knee surgery. However, there are limited data regarding actual joint loading.
Methods: Instrumented knee implants with telemetric data transmission were used to measure the tibiofemoral contact forces. Data were obtained in 9 subjects, during ergometer cycling and walking, 15 ± 7 months after total knee arthroplasty. Tibiofemoral forces during cycling at power levels between 25 and 120 W, cadences of 40 and 60 rpm, and 2 seat heights were investigated.
Results: Within the examined power range, tibiofemoral forces during cycling were smaller than those during walking. At the moderate condition of 60 W and 40 rpm, peak resultant forces of 119% of body weight were measured during the pedal downstroke. Shear forces ranged from 5% to 7% of body weight. Forces increased linearly with cycling power. Higher cadences led to smaller forces. A lower seat height did not increase the resultant force but caused higher posterior shear forces.
Conclusion: Due to the relatively small tibiofemoral forces, cycling with moderate power levels is suited for individuals with osteoarthritis and rehabilitation programs following knee surgery, such as cartilage repair or total knee replacement. The lowest forces can be expected while cycling at a low power level, a high cadence, and a high seat height.
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http://dx.doi.org/10.2519/jospt.2012.4001 | DOI Listing |
Langmuir
September 2025
College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, PR China.
Hard carbon (HC) has emerged as a promising anode material for sodium-ion batteries (SIBs) owing to its superior sodium storage performance. However, the high cost of conventional HC precursors remains a critical challenge. To address this, coal─a low-cost, carbon-rich precursor─has been explored for HC synthesis.
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September 2025
Department of Brain Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Rodents' ability to encode the whisking phase has been extensively documented through neuronal recordings from ascending sensory pathways. Yet, while indicating that reafference originates from the mechanoreceptors, the mechanistic underpinnings of the whisking phase encoding within the follicle remain unclear. Here we present anatomical, histological, and biomechanical evidence for the presence of a distinctive elastic segment (ES) within the basal part of the whisker shaft inside the follicle.
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September 2025
Department of Biology, University of Ottawa, Ottawa, Ontario, Canada.
Long-duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long-term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to adverse outcomes. Developing adverse outcome pathways (AOPs) relevant to radiation exposure can guide research priorities and inform risk assessments of future space exploration activities.
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September 2025
Department of Stomatology, Air Force Medical Center, Air Force Medical University, 30 Fucheng Road, Beijing, 100142, PR China.
TP53TG1 is a long non-coding RNA related to the TP53 gene, which plays an important role in various biological processes such as tumorigenesis, cell cycle regulation, and DNA damage repair. In recent years, researchers have begun to explore the role of TP53TG1 in dental pulp biology, especially its potential impact on pulpitis and other pulp-related diseases. However, the role of TP53TG1 in human dental pulp stem cells (hDPSCs) remains unclear.
View Article and Find Full Text PDFNat Commun
September 2025
Theoretical and Computational Systems Biology Program, Institute for Integrative Systems Biology (I2SysBio), CSIC-UV, Paterna, Spain.
Bacteria often encounter physico-chemical stresses that disrupt division, leading to filamentation, where cells elongate without dividing. Although this adaptive response improves survival, it also exposes filaments to significant mechanical strain, raising questions about the mechanochemical feedback in bacterial systems. In this study, we investigate how mechanical strain modifies the geometry of bacterial filaments and influences the Min oscillatory system, a reaction-diffusion network central to division in Escherichia coli.
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