Delivery systems and local administration routes for therapeutic siRNA.

Pharm Res

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.

Published: April 2013


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Article Abstract

With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA delivery systems for local administration. Moreover, the main disease targets for the local delivery of siRNA to specific tissues or organs, including the skin, the lung, the eye, the nervous system, the digestive system and the vagina, were explored.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088712PMC
http://dx.doi.org/10.1007/s11095-013-0971-1DOI Listing

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