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Background: The differential diagnosis of adrenal pathology depends on the child's age and imaging findings.
Case Report: Three children without clinical symptoms of neoplasm, with an adrenal lesion discovered on diagnostic ultrasound imaging. Laboratory tests for neoplasm were negative. The final diagnosis was based on histopathological examinations after surgical resection.
Conclusions: 1. The value of diagnostic imaging and laboratory tests in differential diagnosis of adrenal gland lesions is limited. 2. Malignant tumors of adrenal glands should be taken into account in children. 3. Surgical resection should be considered in diagnostic algorithm of adrenal gland masses. 4. The final diagnosis is always based on histopathological examination.
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http://dx.doi.org/10.12659/pjr.882975 | DOI Listing |
Acta Vet Hung
September 2025
4Department of Internal Medicine, University of Veterinary Medicine Budapest, István Street 2, 1078 Budapest, Hungary.
The low dose dexamethasone stimulation test (LDDST) is routinely used in canine medicine but in the few cases in guinea pigs diagnosed with hypercortisolism, the adrenocorticotropic hormone (ACTH) stimulation test was used. The objective of the authors was to conduct a pilot study and find out if the standard test used in dogs can be used in this species.A 4-year-old intact female hairless guinea pig showed bilaterally enlarged adrenal glands and high cortisol levels.
View Article and Find Full Text PDFEur J Endocrinol
September 2025
Endocrinology & Nutrition Department. Hospital Universitario Ramón y Cajal Madrid, Spain & Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain.
Objective: The indication for laparoscopic partial adrenalectomy (LPA) in patients with primary aldosteronism due to aldosterone-producing adenoma (APA) remains controversial. This study aimed to determine the functional and surgical outcomes of LPA in this context.
Methods: This is a systematic review and meta-analysis.
Radiol Phys Technol
September 2025
Radiation and Proton Therapy Center, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-Cho, Shizuoka, 411-8777, Japan.
In therapy with Synchrony® mounted on Radixact®, the fiducial marker (FM) and adrenal gland metastasis, which shift with respiratory phase, require margin compensation for high-dose prescriptions. Although compensation is critical, no studies have examined the margin to compensate for the respiratory phase shift. Therefore, we aimed to suggest the compensating margin for the FM and adrenal metastasis shift along with respiratory phase.
View Article and Find Full Text PDFJ Mol Endocrinol
September 2025
INSERM, UMRS 1166, Hôpital La Pitié Salpetriere, Sorbonne Université, Paris, France.
Aldosterone is synthesized by the CYP11B2 enzyme, primarily in the zona glomerulosa of the adrenal gland. It exerts its classical effects on sodium and water balance in the renal distal nephron through binding to the mineralocorticoid receptor (MR). Excess aldosterone production or overactivation of the MR outside the distal nephron leads to cardiac, renal, and vascular injury by increasing oxidative stress and activating the inflammatory and fibrotic pathways.
View Article and Find Full Text PDFFood Funct
September 2025
College of Basic Medicine, Harbin Medical University, Heilongjiang 163319, China.
This study investigated the advantages of gerbils as a sympathetic nervous system (SNS)-driven model for non-alcoholic fatty liver disease (NAFLD) and evaluated the therapeutic potential of soy isoflavones (SIFs). Gerbils exhibited unique SNS characteristics, with an adrenal gland-to-kidney weight ratio 2-3 times higher than that of C57BL/6 mice and Wistar rats, demonstrating elevated levels of adrenaline (AE) and noradrenaline (NE) as well as more pronounced anxiety-like behaviors, indicating enhanced SNS activity. Additionally, gerbils possessed liver lipid metabolism and storage capacities similar to humans, along with a simple genetic background, allowing them to more accurately reflect the pathogenesis of NAFLD.
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