98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950923 | PMC |
http://dx.doi.org/10.1111/j.1742-481X.2012.01047.x | DOI Listing |
Health Inf Sci Syst
December 2025
School of Information Science and Automation, Northeastern University, Shenyang, 110819 China.
Accurate prediction of drug-target interactions (DTIs) is crucial for improving the efficiency and success rate of drug development. Despite recent advancements, existing methods often fail to leverage interaction features at multiple granular levels, resulting in suboptimal data utilization and limited predictive performance. To address these challenges, we propose CF-DTI, a coarse-to-fine drug-target interaction model that integrates both coarse-grained and fine-grained features to enhance predictive accuracy.
View Article and Find Full Text PDFNeurotrauma Rep
August 2025
Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Recent investments in large-scale mortem tissue collection have accelerated opportunities to understand the neuropathology of traumatic brain injury (TBI) and post-traumatic neurodegeneration (PTND). Clinicopathological correlation requires ante-mortem clinical information. Post-mortem family interviews (PFIs) are an established method to capture comprehensive ante-mortem clinical information.
View Article and Find Full Text PDFAust J Rural Health
October 2025
Department of Rural Health, University of Newcastle, Tamworth, New South Wales, Australia.
Aims: Workforce maldistribution is a challenge to the equitable provision of healthcare in Australia. This Commentary details how a multi-university, large-scale, and growing data asset is positioned to contribute strategically and operationally to addressing national workforce priorities.
Context: The Nursing and Allied Health Graduate Outcome Tracking (NAHGOT) study is a prospective longitudinal research project with a commitment to nationwide geographical coverage.
J Environ Manage
September 2025
Department of Mechanical Engineering, University of Colorado Boulder, 1111 Engineering Drive, Boulder, CO, USA. Electronic address:
This study assesses the performance of the ADMS-Urban dispersion model in estimating 1-h mean nitrogen dioxide (NO) concentrations within the street canyons of Prague. While traditional air quality modeling that relies on sparse data from localized monitoring stations, this approach pioneers the integration of traffic, background, and rooftop sensor network, to archive a more granular validation of model outputs. The results demonstrate robust model performance, with FAC2 values ranging from 0.
View Article and Find Full Text PDFBMJ Case Rep
September 2025
Surgical Oncology, Cancer Institute WIA and Research Centre, Chennai, Tamilnadu, India.
Granular cell tumour is a rare benign neoplasm, making up about 0.5% of all soft tissue tumours. Although mostly indolent, a small percentage can become malignant.
View Article and Find Full Text PDF