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Background: Since the introduction of mobile bearing total knee designs nearly 30 years back, many studies have been done to evaluate its long-term result. Comparison with fixed bearing designs has been done in the past, but the studies were confounded by variables such as disease, surgeon, bone quality, pain tolerance, etc. We attempt to eliminate these variables in this study.
Methods: A total of 50 patients who had bilateral arthritis of the knee with similar deformity and pre-operative range of motion on both sides agreed to have one knee replaced with mobile bearing total knee design (PFC-RP) and the other with a fixed bearing design (PFC Sigma) were prospectively evaluated. Comparative analysis of both the designs was done at a mean follow-up of 40 months, minimizing patient, surgeon and observer related bias. Clinical and radiographic outcome, survival and complication rates were compared.
Results: At a mean follow-up of 40 months (range 36-47 months), no benefit of mobile bearing (PFC-RP) over fixed bearing design (PFC Sigma) could be demonstrated with respect to Knee Society scores, pain scores, range of flexion, subject preference or patello-femoral complication rates. Radiographs showed no difference in prosthetic alignment. No patient required a revision surgery till last follow-up.
Conclusions: Our study demonstrated no advantage of the mobile-bearing arthroplasty over fixed bearing arthroplasty with regard to clinical results at short-term follow-up. However, longer follow-up is necessary to confirm whether these results are sustained.
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http://dx.doi.org/10.1007/s00402-012-1482-y | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Integrative Biology, University of California, Berkeley, CA 94720-3140.
Microscale symbioses can be critical to ecosystem functions, but the mechanisms of these interactions in nature are often cryptic. Here, we use a combination of stable isotope imaging and tracing to reveal carbon (C) and nitrogen (N) exchanges among three symbiotic primary producers that fuel a salmon-bearing river food web. Bulk isotope analysis, nanoSIMS (secondary ion mass spectrometry) isotope imaging, and density centrifugation for quantitative stable isotope probing enabled quantification of organism-specific C- and N-fixation rates from the subcellular scale to the ecosystem.
View Article and Find Full Text PDFOper Orthop Traumatol
September 2025
Sektion Sportorthopädie, TUM Universitätsklinikum, Ismaninger Str. 22, 81675, München, Deutschland.
Objective: Anatomical reconstruction of the posterior cruciate ligament (PCL) with suture tape augmentation to enhance primary stability.
Indications: Acute or chronic PCL ruptures, either isolated or as part of multiligamentous injuries, in cases of symptomatic instability or failure of conservative treatment.
Contraindications: Fixed posterior drawer, active infection, bony avulsion.
Sci Adv
September 2025
State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, College of Ecology, Lanzhou University, Lanzhou, P. R. China.
Chromosomal fissions and fusions are common, yet the molecular mechanisms and implications in speciation remain poorly understood. Here, we confirm a fission event in one zokor species through multiple-omics and functional analyses. We traced this event to a mutation in a splicing enhancer of the DNA repair gene in the fission-bearing species, which caused exon skipping and produced a truncated protein that disrupted DNA repair.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
Key Laboratory of Special Functional Materials Manufacturing Processes and Equipment Ministry of Education, College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
The development of environmentally friendly solid lubricants with exceptional wear resistance is imperative to address the escalating environmental concerns and performance limitations of conventional lubricants in demanding tribological applications. This study systematically investigated the wear resistance of hydroxypropyl methylcellulose (HPMC)/tungsten disulfide (WS)/graphene composites under normal applied loads (2 and 4 N) and varying solid lubricant contents (stoichiometric ratios of 0.2 referred to as CWG-0.
View Article and Find Full Text PDFJ Orthop
December 2025
Department of Orthopaedics, Jichi Medical University, Shimotsuke, Japan.
Background: An overhang of the tibial baseplate in unicompartmental knee arthroplasty (UKA) has been associated with postoperative pain and impaired function.
Hypothesis: There are significant patient factors that influence the insertion of a size 1 minimum-sized tibial baseplate in fixed-bearing (FB) UKA for Japanese patients with varus knee osteoarthritis (KOA).
Purpose: This study investigated the above-hypothesized factors.