Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To determine the optimal positive end-expiratory pressure (PEEP) according to inflation and deflation pressure-volume curve (P-V curve) in patients with acute respiratory distress syndrome (ARDS).
Methods: ARDS models were reproduced in 20 dogs, and they were randomly divided into two groups. In both groups, Levenberg-Marquardt iterative algorithm was employed using software to explore parameters fitting with Boltzmann formula, by which the real inflection point of pressure (Pinf d) in deflation limb or lower inflection point pressure (PLip) in inflation limb on P-V curve were defined. For the control group (inflation curve) P-V curve of PLip + 2 cm H(2)O [1 cm H(2)O = 0.098 kPa] was applied as the best PEEP value. In the experimental group (deflation curve) the Pinf d was taken as the best PEEP value. The heart rate (HR), blood pressure (BP), fingertip pulse oxygen saturation [SpO(2)], static lung compliance (Cst), arterial partial pressure of oxygen [PaO(2)] and arterial partial pressure of carbon dioxide [PaCO(2)] were monitored at 0, 2, 6, 12, 24 and 48 hours.
Results: Oxygenation index increased significantly both in control and experimental groups. In experimental group, oxygenation index (mm Hg, 1 mm Hg = 0.133 kPa) of 12, 24 and 48 hours was respectively significantly higher than that of the control group (12 hours: 177.63 ± 8.94 vs. 165.60 ± 8.90, 24 hours: 194.19 ± 10.67 vs. 168.70 ± 10.60, 48 hours: 203.15 ± 13.21 vs. 171.26 ± 9.21, all P < 0.01). Cst [ml/cm H(2)O] at 2, 6, 12, 24 and 48 hours was respectively higher than that of the control group (2 hours: 41.00 ± 4.17 vs. 36.20 ± 3.90, 6 hours: 44.00 ± 4.65 vs. 36.88 ± 3.39, 12 hours: 46.92 ± 5.47 vs. 37.92 ± 3.10, 24 hours: 42.83 ± 8.97 vs. 37.92 ± 3.09, 48 hours: 42.64 ± 9.04 vs. 37.97 ± 2.98, P < 0.05 or P < 0.01).
Conclusion: Determining optimal PEEP for ARDS with deflation P-V curve was better than that of inflation curve.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Stomatal regulation, leaf water relations, and leaf phenology are coordinated in tree species from the Sonoran Desert.
AoB Plants
October 2025
Instituto de Ecología, Departamento de Ecología de la Biodiversidad, Universidad Nacional Autónoma de México, Campus Hermosillo, Luis Donaldo Colosio s/n, Los Arcos, Hermosillo, Sonora CP 83250, México.
To cope with heat and water stress, evergreen and deciduous species from hot and arid deserts should adjust their stomatal conductance ( ) and leaf water potential (Ψ) regulation in response to changes in soil water availability, high temperatures, and vapour pressure deficits (VPDs). To test whether phenology induces changes in -Ψ coordination, we tested for associations between 14 leaf traits involved in leaf economics, hydraulics, and stomatal regulation, including minimum seasonal water potential (Ψ) and maximum ( ), turgor loss point (Ψ), osmotic potential (Ψ), leaf area (LA), and specific leaf area (SLA), across 12 tree species from the Sonoran Desert with contrasting phenology. We found that foliar phenology, leaf hydraulics, and leaf economic traits are coordinated across species and organized along the axis of physiological efficiency and safety in response to temperature and VPD.
View Article and Find Full Text PDF[Coronary heart disease-a German paradox : Using AI-based technology to solve a relevant healthcare problem].
Herzschrittmacherther Elektrophysiol
September 2025
Deutsche Stiftung für chronisch Kranke (DScK), Fürth, Deutschland.
The German healthcare system is facing challenges in diagnosing coronary artery disease (CAD). These include high mortality rates, even when advanced medical technology is used, and an excessive number of coronary angiographies. A key issue is that current guideline models inaccurately estimate pretest probability (PTP).
View Article and Find Full Text PDFExamining the Performance of Polygenic Risk Scores for Alzheimer Disease Within and Across Populations Using -Fold Cross-Validation.
Neurol Genet
December 2024
From the Department of Population and Quantitative Health Sciences (M.D.O., Y.E.S., A.L., K.M., N.R.W., J.B., W.S.B., J.L.H.); Cleveland Institute for Computational Biology (M.D.O., Y.E.S., A.L., W.S.B., J.L.H.), Case Western Reserve University, OH; Department of Medicine (Biomedical Genetics) (L.A.
Background And Objectives: Alzheimer disease (AD) has a complex etiology with a strong genetic component. Despite mounting evidence that genetic risk effect sizes vary by population, most research on the genetics of AD has examined only data sets of individuals with European ancestry. In this study, we investigate the variable performance and transferability of polygenic risk scores (PRSs) by deriving a PRS from analyses of AD for various race and ethnic categories and applying this across groups using a -fold cross-validation approach.
View Article and Find Full Text PDFPerformance of Radiomics and Deep Learning Models in Predicting Distant Metastases in Soft Tissue Sarcomas: A Systematic Review and Meta-analysis.
Acad Radiol
July 2025
Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, Seattle, WA (P.M., S.H., H.S.K., A.A., M.C.). Electronic address:
Rationale And Objectives: Predicting distant metastases in soft tissue sarcomas (STS) is vital for guiding clinical decision-making. Recent advancements in radiomics and deep learning (DL) models have shown promise, but their diagnostic accuracy remains unclear. This meta-analysis aims to assess the performance of radiomics and DL-based models in predicting metastases in STS by analyzing pooled sensitivity and specificity.
View Article and Find Full Text PDFLDL-Bound PCSK9 Has a Slower Clearance Kinetic and Higher Use for HSPGs Than Free-PCSK9-Brief Report.
Arterioscler Thromb Vasc Biol
September 2025
Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland (S.C.P.-V., C.O., J.H., P.A.M., J.M., H.T., S.F., N.P.).
Background: Hepatic heparan sulfate proteoglycans (HSPGs) accelerate the clearance of PCSK9 (proprotein convertase subtilisin/kexin type 9). We tested the hypothesis that free- and LDL (low-density lipoprotein)-bound PCSK9 forms have different HSPG-mediated clearance kinetics.
Methods: Metabolic and turnover studies were performed after administration of free- and LDL-bound PCSK9 to 2 HSPG knockout mouse models: (1) Global knockout of syndecan-1 (), an HSPG involved in hepatic triglyceride clearance; and (2) hepatocyte-specific knockout of heparan sulfate N-deacetylase/N-sulfotransferase ).