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Increased Plasma ST2 Levels Precede the Development of Severe Acute GvHD and Chronic GvHD After Pediatric Hematopoietic Stem Cell Transplantation.
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Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Background: The suppressor of tumorigenesis 2 (ST2) has emerged as one of the most promising biomarkers for predicting mortality of acute graft-versus-host disease (aGvHD) when measured at the onset of symptoms, but detailed time course studies are needed to understand the potential of ST2 as a risk marker of both aGvHD and chronic graft-versus-host disease (cGvHD), potentially allowing pre-emptive adjustment of immunosuppressive treatment.
Procedure: We measured ST2 levels in 117 children undergoing standard hematopoietic stem cell transplantation (HSCT) before conditioning and at regular intervals post-HSCT.
Results: ST2 levels were significantly increased from Day +7 in patients developing aGvHD of any grade (no GvHD: 23.
Spontaneous Recanalization of Left Middle Cerebral Artery Occlusion Beyond the Thrombolysis Window.
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Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Large vessel occlusion (LVO)-induced acute ischemic stroke (AIS) manifests with abrupt onset and critical severity, primarily caused by cerebral artery atherosclerosis or cardiogenic embolism leading to luminal stenosis or occlusion. The authors report a case of acute massive cerebral infarction caused by occlusion of the left middle cerebral artery (MCA) and missed the time window for thrombolysis, in which spontaneous recanalization of the MCA was achieved after 1 week of conservative treatment. After 2 months of rehabilitation training, neurological functions and other symptoms significantly improved.
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Background: Given the recency of the COVID-19 pandemic, few studies focus on the challenges frontline healthcare providers (HCPs) face in Saudi Arabia. There aren't many studies that specifically address the difficulties Saudi Arabia's frontline nurses confront due to the COVID-19 pandemic's recent onset.
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Platelet dynamics and thrombocytopenia in dengue fever: A prospective cohort study from Shenzhen, China.
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Introduction: Dengue fever, the most prevalent arthropod-borne viral disease, causes ∼400 million infections annually. Although thrombocytopenia is commonly associated with dengue, how it evolves in relation to viral load and immune responses remains poorly understood. This study aimed to elucidate platelet-virus-immune interactions in acute dengue by systematically tracking of viral load, platelet parameters, and leukocyte dynamics.
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