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We report the management of a 64-year-old male with newly diagnosed bulbar-onset myasthenia gravis (MG) who was hospitalized with acute neuromuscular respiratory insufficiency. This case highlights the challenges in monitoring respiratory function in MG patients, especially in the presence of bulbar and nuchal weakness, and emphasizes the potential utility of single breath-hold time (SBHT) over forced vital capacity (FVC) as a reliable bedside monitoring tool. Despite initial stabilization with intravenous immunoglobulin (IVIG), the patient deteriorated, requiring escalation to the intensive care unit (ICU), and the clinical worsening corresponded with the SBHT rather than with FVC.
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http://dx.doi.org/10.7759/cureus.89538 | DOI Listing |
Pflugers Arch
September 2025
Department of Science, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
Hypoxia has been extensively studied as a stressor which pushes human bodily systems to responses and adaptations. Nevertheless, a few evidence exist onto constituent trains of motor unit action potential, despite recent advancements which allow to decompose surface electromyographic signals. This study aimed to investigate motor unit properties from noninvasive approaches during maximal isometric exercise in normobaric hypoxia.
View Article and Find Full Text PDFTrauma Surg Acute Care Open
September 2025
CRT 4, US Army Institute of Surgical Research Burn Center, Fort Sam Houston, Texas, USA.
Acute extremity compartment syndrome (CS) is a serious medical complication triggered by factors such as trauma, vascular injury, or prolonged compression, resulting in elevated intracompartmental pressure (ICP) and tissue ischemia. Diagnosis remains challenging, mainly relying on the subjective evaluation of clinical symptoms. Different animal models have been used to study pathophysiology and evaluate diagnostic and therapeutic approaches.
View Article and Find Full Text PDFCureus
August 2025
Respiratory Medicine, Birmingham Heartlands Hospital (Part of University Hospitals Birmingham NHS Trust), Birmingham, GBR.
We report the management of a 64-year-old male with newly diagnosed bulbar-onset myasthenia gravis (MG) who was hospitalized with acute neuromuscular respiratory insufficiency. This case highlights the challenges in monitoring respiratory function in MG patients, especially in the presence of bulbar and nuchal weakness, and emphasizes the potential utility of single breath-hold time (SBHT) over forced vital capacity (FVC) as a reliable bedside monitoring tool. Despite initial stabilization with intravenous immunoglobulin (IVIG), the patient deteriorated, requiring escalation to the intensive care unit (ICU), and the clinical worsening corresponded with the SBHT rather than with FVC.
View Article and Find Full Text PDFFront Physiol
August 2025
Facultad de Ciencias Biomédicas y de la Salud, Universidad Alfonso X el Sabio (UAX), Madrid, Spain.
Training structures such as every minute on minute (EMOM), as many repetitions as possible (AMRAP), and rounds for time (RFT) have gained popularity for improving sport performance and general health. However, limited research exists on how different relative loads affect neuromuscular and cardiorespiratory responses. This study aimed to compare acute effects on heart rate (HR), mean propulsive velocity (MPV), velocity loss, and pacing in participants performing AMRAP, EMOM, and RFT using the same absolute but varying relative loads.
View Article and Find Full Text PDFPercept Mot Skills
September 2025
Department of Physical Education and Health, Higher Institute of Physical Education, University of the Republic, Montevideo, Uruguay.
Tabata-based High-Intensity Functional Training (HIFT) elicits hybrid adaptations in both cardiorespiratory and neuromuscular systems. However, its high Rating of Perceived Exertion (RPE) may limit its feasibility. This study aimed to analyze the acute physiological and psychological responses to a modified low-volume Tabata-based HIFT incorporating short efforts, with a focus on potential differences between sexes.
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