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Article Abstract
Sweet screens: A high-throughput screening platform for identification of inhibitors of sialyl- and fucosyltransferases based on fluorescence polarization (FP) has been developed. An analogue of the natural donor substrate carrying a fluorescent label (green star) is transferred to a glycoprotein acceptor, which results in robust FP. The screening of 16,000 compounds against different glycosyltransferases has identified various interesting inhibitors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245354 | PMC |
| http://dx.doi.org/10.1002/anie.201105065 | DOI Listing |
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