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Immobilized biomineralizing protein Mms6 templates the formation of uniform magnetite nanoparticles in situ when selectively patterned onto a surface. Magnetic force microscopy shows that the stable magnetite particles maintain their magnetic orientation at room temperature, and may be exchange coupled. This precision-mixed biomimetic/soft-lithography methodology offers great potential for the future of nanodevice fabrication.
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http://dx.doi.org/10.1002/smll.201101627 | DOI Listing |
Langmuir
June 2025
Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science & Engineering, Fudan University, Shanghai 200438, China.
Rapid on-site pathogen detection is of paramount importance to prevent widespread bacterial infection. In this work, we successfully developed a dual-mode pathogen detection platform based on a horseradish peroxidase (HRP) @ magnetic zeolitic imidazole framework (HMZIF). By using HRP as a biotemplate and an optimal combination of ligand and salts, the HMZIF can be readily obtained through an innovative one-pot biomineralization process without incorporation of additional magnetic nanoparticles.
View Article and Find Full Text PDFACS Appl Mater Interfaces
May 2025
School of Mechanical Engineering and Automation, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100191, China.
Magnetic micro/nanorobots have been extensively studied for their potential in targeted drug delivery. However, facile fabrication of magnetic microrobots with good biocompatibility and enhanced chemo-photothermal therapeutic efficiency is still challenging. Here, we proposed a novel strategy for mass production of MOF-loaded biotemplated magnetic microrobots based on and verified its feasibility for application in targeted chemo-photothermal therapy.
View Article and Find Full Text PDFACS Appl Mater Interfaces
April 2025
School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China.
Neuroblastoma, a highly malignant pediatric tumor, demands innovative targeted drug delivery strategies to overcome the limitations of conventional therapies. In this study, we developed magnetic diatom microrobots (DMs) using diatom frustules as biotemplates, leveraging their natural hierarchical porosity and biocompatibility. Functionalized with amino groups and folic acid, these microrobots demonstrated enhanced drug conjugation and tumor-targeting capabilities.
View Article and Find Full Text PDFACS Nano
March 2025
Beijing Key Laboratory for Magnetoelectric Materials and Devices, School of Materials Science and Engineering, Peking University, Beijing 100871, China.
Cancer poses a substantial threat and a serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, and tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge as promising therapeutic candidates that provide alternative strategies for cancer therapy. MNR is a kind of human-made machine that is micro- or nanosized, is reasonably designed, and performs command tasks through self-actuated or externally controlled propulsion mechanisms, which can be potentially applied in cancer theranostics.
View Article and Find Full Text PDFACS Appl Mater Interfaces
February 2025
School of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Magnetic microrobots hold great promise for applications in drug delivery and environmental remediation, but achieving collective reconfiguration and effective propulsion for dense, motile magnetic microrobots remains a significant challenge. In this research, we have fabricated -based biohybrid magnetic microrobots in bulk using a facile biotemplating process and studied their superior reconfiguration and propulsion performance. Our results show that the dispersed superparamagnetic individuals can self-organize into a swarm of chain-like multimers, achieving effective propulsion via rolling or tumbling modes.
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