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We present a Bessel beam illumination FDOCT setup using a FDML Swept Source at 1300 nm with up to 440 kHz A-scan rate, and discuss its advantages for structural and functional imaging of highly scattering samples. An extended focus is achieved due to the Bessel beam that preserves its lateral extend over a large depth range. Furthermore, Bessel beams exhibit a self-reconstruction property that allows imaging even behind obstacles such as hairs on skin. Decoupling the illumination from the gaussian detection increases the global sensitivity and enables dark field imaging. Dark field imaging is useful to avoid strong reflexes from the sample surface that adversely affect the sensitivity due to the limited dynamic range of high speed 8 bit acquisition cards. In addition the possibility of contrasting capillaries with high sensitivity is shown, using inter-B-scan speckle variance analysis. We demonstrate intrinsic advantages of the extended focus configuration, in particular the reduction of the phase decorrelation effect below vessels leading to improved axial vessel definition.
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http://dx.doi.org/10.1364/OE.19.012141 | DOI Listing |
Int J Biol Macromol
September 2025
Department of Food, Nutrition and Packaging Sciences, Clemson University, Clemson, SC, 29634, USA. Electronic address:
Sepiolite (SP) is a naturally occurring sedimentary silicate clay mineral known for its unique structure, high surface area, and rich surface chemistry, particularly silanol groups (Si-OH), which facilitate strong interfacial interactions in polymer matrices. Its ability to act as a nanofiller has gained attention in the development of advanced biopolymer nanocomposites, especially for food packaging applications where material performance, sustainability, and safety are critical. SP enhances the thermal stability, barrier properties, and mechanical strength of starch and other biopolymer matrices, key factors in extending shelf life.
View Article and Find Full Text PDFJ Control Release
September 2025
Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 14b, 50411 Tartu, Estonia; Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA. Electronic address:
Most chemotherapeutics distribute non-specifically throughout the body, resulting in off-target toxicities. Nanoparticle (NP) formulations provide a strategy to improve drug delivery by extending circulation time, protecting therapeutic agents from degradation, and enabling controlled release. However, delivering NPs effectively to solid tumors remains challenging due to the barriers within the tumor microenvironment.
View Article and Find Full Text PDFNurse Educ Pract
September 2025
Edith Cowan University, School of Nursing and Midwifery, 270 Joondalup Drive, Joondalup, WA 6027, Australia.
Aim: To co-design a resilience-based mentoring program for novice midwives in Western Australia, informed by the experiences of past midwifery graduates and the perspectives of midwives in senior roles.
Background: Effective workforce planning and retention strategies are essential in preventing the continued loss of midwives and in attracting newly qualified midwives to healthcare organisations. Transitioning from student to registered midwife is a known period of vulnerability that requires structured, evidence-informed support.
J Refract Surg
September 2025
From the Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany and.
Purpose: To evaluate intraocular lens (IOL) power calculation of a non-diffractive extended depth of focus (EDOF) IOL after myopic laser in situ keratomileusis (LASIK) without historical data.
Methods: In this consecutive case series, patients who had undergone lens surgery with implantation of a non-diffractive EDOF IOL after myopic laser in situ keratomileusis (LASIK) at the Department of Ophthalmology, University Hospital Frankfurt, Frankfurt, Germany, were included. Preoperative assessments included biometry and tomography using Scheimpflug technology (Pentacam; Oculus Optikgeräte GmbH).
Brain Behav
September 2025
Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China.
Background: Delirium is an acute cognitive disturbance that is linked to increased healthcare costs, extended hospitalization, and a greater incidence of adverse outcomes, including cognitive decline. Despite its clinical importance, existing strategies for predicting and managing delirium remain inadequate. This study, therefore, sought to investigate the potential relationship between cerebrospinal fluid proteins and delirium via Mendelian randomization (MR) and to identify potential therapeutic targets.
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