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Objective: Current debate centres on the inhibitory and conflict interpretations of the N2 and P3 components of the event-related potential (ERP). We examined behavioural responses and ERPs in a cued-Go/NoGo task.
Methods: Participants were required to inhibit a planned response (NoGo target after Go cue), change a planned response to a different one (Invalid cueing), and activate an unexpected response (Go target after NoGo cue).
Results: Responses were slower when participants had to change a planned response, and execute an unplanned response. N2 was more negative whenever the presented target required a different response to what was expected based on the cue. In contrast, P3 was increased when participants had to change or inhibit a planned response, but not when executing a response where none was planned.
Conclusions: N2 results lend support to the conflict account, while P3 reflects cancellation of a planned response.
Significance: This paper provides the first test of conflict involving activation of an unplanned response in a cued-Go/NoGo task.
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http://dx.doi.org/10.1016/j.clinph.2011.05.012 | DOI Listing |
JMIR Dermatol
September 2025
College of Osteopathic Medicine, Rocky Vista University, 8401 S Chambers Road, Parker, CO, 80112, United States, 1 9253236431.
Dermal fillers have gained increasing popularity for their ability to enhance facial symmetry, restore volume, and improve skin texture. However, their use in patients with cancer undergoing active chemotherapy and radiation therapy poses unique challenges, as these treatments can alter both the safety profile and efficacy of filler procedures. Chemotherapy can interfere with normal wound healing and immune responses, warranting a more cautious and individualized approach when considering dermal fillers in this population.
View Article and Find Full Text PDFJ Affect Disord
September 2025
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada; Seniors Mental Health Program, Department of Psychiatry and Neurosciences, McMaster University, Hamil
Electroencephalography (EEG) is a comparatively inexpensive and non-invasive recording technique of neural activity, making it a valuable tool for biomarker discovery in transcranial magnetic stimulation (TMS). This systematic review aimed to examine mechanistic and predictive biomarkers, identified through TMS-EEG or resting-state EEG, of treatment response to TMS in psychiatric and neurocognitive disorders. Nineteen articles were obtained via Embase, APA PsycInfo, MEDLINE, and manual search; conditions included, unipolar depression (k = 13), Alzheimer's disease (k = 3), bipolar depression (k = 2), and schizophrenia (k = 2).
View Article and Find Full Text PDFInt J Nurs Stud
August 2025
Florence Nightingale Faculty of Nursing Midwifery and Palliative Care, Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, Bessemer Road, London SE5 9PJ, UK; Sussex Community NHS Foundation Trust, Brighton General Hospital, Elm Grove, Brighton, East Sussex
Background: People with advanced illness at home, and their families, rely on 'out-of-hours' services provided by community, primary and specialist palliative care services. Home is commonly expressed as the preferred place to be cared for and die, and an increasing proportion of people are dying at home, but what constitutes 'good' care is poorly understood from the combined perspectives of healthcare professionals and patients and family caregivers.
Objective: To understand the convergence and divergence of the perspectives of healthcare professionals with those of patients and family caregivers, on priorities for home-based palliative care in the 'out-of-hours' period in the UK.
Proc Natl Acad Sci U S A
September 2025
Department of Medicine, Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
The β-adrenergic receptor (βAR), a prototype G protein-coupled receptor, controls cardiopulmonary function underpinning O delivery. Abundance of the βAR is canonically regulated by G protein-coupled receptor kinases and β-arrestins, but neither controls constitutive receptor levels, which are dependent on ambient O. Basal βAR expression is instead regulated by the prolyl hydroxylase/pVHL-E3 ubiquitin ligase system, explaining O responsivity.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Biology, Stanford University, Stanford, CA 94305.
Climate change is expected to pose significant threats to public health, particularly vector-borne diseases. Despite dramatic recent increases in dengue that many anecdotally connect with climate change, the effect of anthropogenic climate change on dengue remains poorly quantified. To assess this link, we assembled local-level data on dengue across 21 countries in Asia and the Americas.
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