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http://dx.doi.org/10.1002/anie.201101604 | DOI Listing |
J Colloid Interface Sci
August 2025
Clinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, PR China. Electronic address:
An ideal wound dressing should possess multiple functions such as self-healing, antibacterial properties, and biodegradability. To achieve this goal, this study utilized the host-guest interaction between adamantane groups and β-cyclodextrin, as well as the Diels-Alder reaction between furan groups and maleimide groups, to prepare a novel dual-network hydrogel (DN-Gel) based on starch and hyaluronic acid. The preparation conditions of DN-Gel were optimized through single-factor experiments.
View Article and Find Full Text PDFACS Biomater Sci Eng
September 2025
The Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
An interpenetrating polymer network (IPN) hydrogel was developed for the three-dimensional (3D) culture of multipotent mesenchymal stromal cells (MSCs) with the aim of independently controlling cell spreading and material modulus. Based on our previous studies, we formulated a semisynthetic material composed of two networks: a covalent network of poly(ethylene glycol) (PEG)-fibrinogen (PF) and a second guest-host (GH) network of hyaluronic acid (HA) coupled to β-cyclodextrin (CD) and adamantane (Ad). The PF network provided cell attachment, precise control over modulus through the incorporation of additional PEG-diacrylate (PEG-DA) cross-linking, and proteolytic degradability.
View Article and Find Full Text PDFMater Horiz
July 2025
Shenzhen Campus of Sun Yat-Sen University, School of Biomedical Engineering, China.
The construction of highly efficient theranostic materials is critical for accurate lesion diagnosis and treatment. Among various diagnostic modalities, magnetic resonance imaging (MRI) is gaining attention due to its safety and precision. This study presents a novel theranostic agent, TPZ@TSF, that integrates F MRI for diagnostic imaging with photodynamic therapy (PDT) and hypoxia-activated tirapazamine (TPZ) as therapeutic modalities.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
August 2025
Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
Heterobifunctional drugs have revolutionized chemical biology and therapeutic innovation, yet their fixed covalent linkages constrain dynamic adaptability. Here, we introduce host-guest bridged lysosome-targeting chimeras (HGTACs), a supramolecular bifunctional platform that utilizes β-cyclodextrin-adamantane host-guest interactions to achieve tunable and modular assembly. HGTACs effectively facilitated lysosomal degradation of both extracellular and transmembrane proteins, including NS-650, epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2.
View Article and Find Full Text PDFNanoscale Adv
June 2025
Center for Soft Nanoscience and Organic Chemistry Institute, University of Münster Busso-Peus-Str. 10 48149 Münster Germany
Herein, we present a pH-sensitive nanoplatform based on Tm/Yb co-doped upconversion nanoparticles (UCNPs) functionalized with β-cyclodextrin (β-CD) and a pH-responsive nitrobenzoxadiazole dye modified with adamantane (NBD-Ad). The host-guest interaction between β-CD on the UCNP surface and Ad on NBD-Ad enables a stable, water-dispersible ratiometric pH sensor. Upon 980 nm excitation, the UCNPs emit in the UV and blue regions, which overlap with the pH-dependent absorption of NBD-Ad.
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