Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Unlabelled: The prolactin plays an important role in the regulation of growth and differentiation of prostate gland besides androgens. The goal of this study was to reveal the influence of elevated prolactin concentration on epithelial cells of prostate. We compared the morphology of epithelial cells of prostate dorsal, lateral and ventral lobes and expression of androgen receptors in these cells in rats with hyperprolactinemia and in control rats. We used sexually mature male Wistar rats. The experimental rats received metoclopramide; the control group received saline in the same way. The prostate dorsal, lateral and ventral lobes were collected routinely for light and electron microscopy. The intensity of immunohistochemical reaction of androgen receptor in epithelial cells of dorsal, lateral and ventral lobes was evaluated by measure of optical density with computer image analysis. The light and electron (transmission and scanning) microscopes were used for morphological observations.
Results: In experimental rats twofold increase in prolactin and twofold decrease in testosterone found. In experimental group the expression of androgen receptor was lower in columnar epithelial cells of dorsal and ventral lobes but higher in lateral one. We observed morphological abnormalities in columnar epithelial cells of lateral and dorsal lobes. The columnar epithelial cells of ventral lobes didn't show any morphological changes in hyperprolactinemia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2478/v10042-010-0074-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Curcumin and quercetin modulate oxidative stress and inflammation of healthy lung cells treated with sol-gel graphene oxide nanoparticles.
Biochem Biophys Res Commun
September 2025
Selcuk University, Faculty of Medicine, Department of Medical Biochemistry, Konya, Turkey. Electronic address:
This study investigates the cytotoxic and biochemical effects of PEGylated graphene oxide sol-gel (SJ-go) nanoparticles, curcumin, and quercetin on BEAS-2B human bronchial epithelial. In this work, a new graphene oxide nanocomposite (SJ-go) was produced using the sol-gel method through a one-step reaction. These hybrid sol-gel systems include graphite, triethyl orthosilicate (TEOS), and polyethylene glycol (PEG) having a molecular weight of 8000 g/mol.
View Article and Find Full Text PDFPatient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis.
Inflamm Bowel Dis
September 2025
Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Background: Intestinal cells receive incoming signals from neighboring cells and microbial communities. Upstream signaling pathways transduce these signals to reach transcription factors (TFs) that regulate gene expression. In inflammatory bowel disease (IBD), most single nucleotide polymorphisms (SNPs) are in non-coding genomic regions containing TF binding sites.
View Article and Find Full Text PDFPleurotus citrinopileatus polysaccharides ameliorate DSS-induced ulcerative colitis by improving intestinal barrier and inflammation modulation via NF-κB pathway.
Int J Biol Macromol
September 2025
Laboratory of Tumor Immunology, The first Hospital of Jilin University, Changchun, 130021, China. Electronic address:
The aim was to investigate the pharmacological effects of a polysaccharide isolated from Pleurotus citrinopileatus on ulcerative colitis (UC). One polysaccharide, CP-2-2, was isolated and purified from P. citrinopileatus body fruit using chromatographic methods.
View Article and Find Full Text PDFLncSSBP1/FOXO3 axis modulates autophagy: a novel insight into bronchial epithelial cells defense against Talaromyces marneffei in-fection.
Microbes Infect
September 2025
Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530007, P.R. China. Electronic address:
Background: While autophagy is pivotal in antimicrobial defense, its regulatory role in Talaromyces marneffei (TM) infected bronchial epithelium remains elusive.
Objective: To elucidate the impact of TM infection on autophagy in bronchial epithelial cells and to identify the key molecular regulators involved in this process.
Methods: Primary computational screening identified core autophagy modulators.
The Glucocorticoid Receptor Inhibits NRF2-Mediated Expression of SLC7A11.
Free Radic Biol Med
September 2025
Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, 55812 USA. Electronic address:
SLC7A11 encodes the glutamate-cystine exchanger xCT, which is a key regulator of intracellular antioxidant capacity and extracellular glutamate levels. We have identified SLC7A11 as a direct target of the glucocorticoid receptor (GR). The GR agonist dexamethasone represses SLC7A11 expression in multiple cell types, from epithelial cells to astrocytes.
View Article and Find Full Text PDF