Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The most appropriate method to preserve Bufferin 81-mg tablets dispensed for unit-dose packaging in the hospital pharmacy was examined. The surface color change of the tablets was investigated over time by spectrophotometry, and the decomposition rate of aspirin was measured by high-performance liquid chromatography (HPLC). To overcome these, it was found that we can effectively prevent color changes and preserve the quality by maintaining the humidity as 55% or less, storage with drying agent in a plastic or aluminum pack. It was revealed that the color changes became greater and the decomposition rate became higher as time passed. Color changes markedly affect the patients' compliance, and are found to be a very important factor. It was considered that the clarity of the correlation between the color change and decomposition rate may contribute to a decrease in the number of tablets discarded before the expiration date.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2010.06.031 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Elucidation of the thermo-kinetics of the thermal decomposition of cameroonian kaolin: mechanism, thermodynamic study and identification of its by-products.
RSC Adv
September 2025
Otto-von-Guericke-University Magdeburg, Chemical Institute, Chair for Industrial Chemistry Universitätsplatz 2 39106 Magdeburg Germany
This work elucidates the thermo-kinetics of the thermal conversion of cameroonian kaolin to metakaolin as the main product. The thermokinetical parameters (activation energy and pre-exponential factor ) for the kaolin conversion were calculated using model-free methods, the Kissinger-Akahira-Sunrose (KAS) and the Flynn-Wall-Ozawa (FWO) method, and differential methods (Kissinger and Ozawa) additionally including iterative procedures for KAS and FWO methods (KAS-Ir; FWO-Ir). The cameroonian kaolin was heat-treated using three different heating rates, 5, 20 and 40 K min, leading to metakaolin samples named MK-(5), MK-(20) and MK-(40).
View Article and Find Full Text PDFSynthesis and performance study of potassium-based flame-retardant groups grafted onto nitrocellulose.
Phys Chem Chem Phys
September 2025
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
To analyse the issues of high muzzle flame intensity and the easy migration of insensitive agents in conventional insensitive propellants, this study synthesizes modified nitrocellulose grafted with carboxymethyl potassium groups by a two-step process, starting from the molecular structure of nitrocellulose (NC), the principal component of propellants. First, the denitration reaction was performed to reduce part of the nitrate ester groups on the surface of NC to hydroxyl groups, followed by an etherification reaction to achieve directional grafting of carboxymethyl potassium groups. Compared with conventional flame retardant/insensitive systems based on nitrogen, phosphorus, or DBP (dibutyl phthalate), potassium-based functional groups exhibit superior thermal stability and environmental friendliness.
View Article and Find Full Text PDFNon-invasive motor unit analysis reveals specific responses during maximal muscle contraction under normobaric hypoxia.
Pflugers Arch
September 2025
Department of Science, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
Hypoxia has been extensively studied as a stressor which pushes human bodily systems to responses and adaptations. Nevertheless, a few evidence exist onto constituent trains of motor unit action potential, despite recent advancements which allow to decompose surface electromyographic signals. This study aimed to investigate motor unit properties from noninvasive approaches during maximal isometric exercise in normobaric hypoxia.
View Article and Find Full Text PDFBeech leaf disease reduces nitrogen retranslocation at leaf fall, altering litter chemistry.
Oecologia
September 2025
Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
Beech leaf disease (BLD) poses a serious threat to the health of beech forests throughout the northeastern USA and Canada. Caused by invasive nematodes, BLD first appeared in 2012 in Ohio and has rapidly spread eastward. We investigated the effects of BLD on leaf and litter chemistry and leaf litter decomposition rate from four infected beech stands in Falmouth, Massachusetts.
View Article and Find Full Text PDFProgress and Perspective on Heterogeneous Catalysis of Liquid Formic Acid Dehydrogenation: Coordination Structure Design, Activity Improvement, and Mechanism Insights.
Adv Mater
September 2025
College of Chemistry, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, P. R. China.
Formic acid (FA) has attracted significant interest as a renewable liquid-phase hydrogen carrier. Hydrogen generation from FA decomposition is essential for the development of hydrogen economy. Designing highly efficient catalysts with different coordination environments for FA dehydrogenation is crucial for fuel-cell applications.
View Article and Find Full Text PDF