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Study Methodology: THIS IS A COMPARATIVE STUDY OF INTRA CANAL STRESS PATTERNS IN ENDODONTICALLY TREATED MAXILLARY CENTRAL INCISOR WITH: average sized canal diameter and wide canals reinforced with three different post systems - cast post and core, carbon fiber post, stainless steel post; restored with ceramic crown using finite element analysis (FEA). All the models were subjected to a force of 100N applied at 450 to the long axis of the tooth at the middle third of the palatal surface of the restored ceramic crown.
Results: The FEA revealed that all the post systems showed maximum stress in the coronal and middle third of the root. Maximum stress was seen on the inner dentinal wall in case of stainless steel post followed by cast gold and carbon fiber post, both in the models without reinforcement as well as in the reinforced models.
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http://dx.doi.org/10.4103/0972-0707.62639 | DOI Listing |
J Orthop Res
September 2025
Department of Kinesiology, College of Health Sciences, University of Rhode Island, Kingston, Rhode Island, USA.
Arthroplasty surgery is a common and successful end-stage intervention for advanced osteoarthritis. Yet, postoperative outcomes vary significantly among patients, leading to a plethora of measures and associated measurement approaches to monitor patient outcomes. Traditional approaches rely heavily on patient-reported outcome measures (PROMs), which are widely used, but often lack sensitivity to detect function changes (e.
View Article and Find Full Text PDFBMC Psychiatry
September 2025
Zentrum Isartal Am Kloster Schäftlarn, Schäftlarn, Germany.
Background: Patients with mental health conditions represent a significant concern in emergency departments, consistently ranking as the third or fourth most prevalent diagnoses during consultations. Globally, over the past two decades, there was a marked increase in such incidences, largely driven by a rise in nonurgent visits related to somatic complaints. However, the implications of these nonurgent visits for mental health patients remain unclear, and warrant further investigation.
View Article and Find Full Text PDFJ Gen Intern Med
September 2025
University of Colorado School of Medicine, 1890 N Revere Ct, Third Floor, Mail Stop F443, Aurora, CO, 80045, USA.
Background: The SHARE Approach Model and training curriculum was developed by the Agency for Healthcare Research and Quality (AHRQ) to teach clinicians practicing in diverse settings how to engage in more effective Shared Decision Making (SDM).
Objective: To determine the effectiveness of the SHARE Approach at improving SDM in practices located across Colorado, USA.
Design: A longitudinal study with pre- and post-intervention observations.
Nature
September 2025
Los Alamos National Laboratory, Los Alamos, NM, USA.
The Perseverance rover has explored and sampled igneous and sedimentary rocks within Jezero Crater to characterize early Martian geological processes and habitability and search for potential biosignatures. Upon entering Neretva Vallis, on Jezero Crater's western edge, Perseverance investigated distinctive mudstone and conglomerate outcrops of the Bright Angel formation. Here we report a detailed geological, petrographic and geochemical survey of these rocks and show that organic-carbon-bearing mudstones in the Bright Angel formation contain submillimetre-scale nodules and millimetre-scale reaction fronts enriched in ferrous iron phosphate and sulfide minerals, likely vivianite and greigite, respectively.
View Article and Find Full Text PDFJ Neurosci
September 2025
College of Life Sciences, Zhejiang University, Hangzhou 310058, P.R. China
Nonsense-mediated mRNA decay (NMD) is a conserved RNA surveillance mechanism that degrades transcripts with premature termination codons (PTCs) and finetunes gene expression by targeting RNA transcripts with other NMD inducing features. This study demonstrates that conditional knockout of , a key NMD component, in oligodendrocyte lineage cells disrupts the degradation of PTC-containing transcripts, including aberrant variants of the RNA-binding protein The loss of SMG5 in both sexes of mice impaired oligodendrocyte differentiation, reduced myelin gene expression, and led to thinner myelin sheaths and compromised motor function in mice. Mechanistically, HNRNPL was shown to regulate the alternative splicing of myelin-associated genes and , and promote oligodendrocyte differentiation.
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