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Stroke
September 2025
Department of Neurology, Yale School of Medicine, New Haven, CT (L.H.S.).
Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (mpRCTs) that mimic phase 3 clinical trials in several key components. This collective statement, derived from experts involved in mpRCTs, outlines considerations for designing and executing such trials.
View Article and Find Full Text PDFNature
September 2025
Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, USA.
Nature
September 2025
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Loss-of-function variants in the lipid transporter ABCA7 substantially increase the risk of Alzheimer's disease, yet how they impact cellular states to drive disease remains unclear. Here, using single-nucleus RNA-sequencing analysis of human brain samples, we identified widespread gene expression changes across multiple neural cell types associated with rare ABCA7 loss-of-function variants. Excitatory neurons, which expressed the highest levels of ABCA7, showed disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways.
View Article and Find Full Text PDFJ Safety Res
September 2025
University of Massachusetts Amherst, 160 Governors Drive, Amherst, MA 01002, USA. Electronic address:
Introduction: Effective driver education for teen drivers is increasingly important, especially as Advanced Driver Assistance Systems (ADAS) become standard in modern vehicles. This study examines driver education programs in the commonwealth of Massachusetts and explores how they are placed to prepare young drivers to understand and safely use ADAS technologies.
Method: Through a convergent mixed-methods approach, we analyzed thematic data from interviews and surveys of key stakeholders and performed sentiment analysis to capture their concerns and attitudes.
Ann N Y Acad Sci
September 2025
BioAnalyt, Teltow, Germany.
Big data analytics have shown great potential to improve decision-making in health, including disease surveillance and healthcare delivery. This scoping review explores how big data supports decision-making in large-scale food fortification (LSFF) and biofortification across the food value chain. Following PRISMA guidelines, we analyzed open-access peer-reviewed literature and gray literature from 2012 to 2022.
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